十全大补汤合五味消毒饮加减对食管癌术后气血亏虚证患者免疫功能的影响

杨爱娣; 向锋; 杨丽娜; 王友于; 张允; 张琨

doi:10.13422/j.cnki.syfjx.2016110174

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十全大补汤合五味消毒饮加减对食管癌术后气血亏虚证患者免疫功能的影响

临床 | 更新时间：2024-01-04

- 十全大补汤合五味消毒饮加减对食管癌术后气血亏虚证患者免疫功能的影响
- Effect of Shiquan Dabu Tang Combined with Wuwei Xiaodu Yin on Immune Functions in Postoperative Qi and Blood Deficiency Patients with Esophagus Cancer
- 中国实验方剂学杂志 2016年22卷第11期页码：174-178
- 作者机构：
- 作者简介：
- 基金信息：
  
  四川省人民医院院级苗圃课题项目(2015MP44)
- DOI：10.13422/j.cnki.syfjx.2016110174
  中图分类号： R273
- 纸质出版日期：2016
- 稿件说明：
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杨爱娣, 向锋, 杨丽娜, 等. 十全大补汤合五味消毒饮加减对食管癌术后气血亏虚证患者免疫功能的影响[J]. 中国实验方剂学杂志, 2016,22(11):174-178.

YANG Ai-di, XIANG Feng, YANG Li-na, et al. Effect of Shiquan Dabu Tang Combined with Wuwei Xiaodu Yin on Immune Functions in Postoperative Qi and Blood Deficiency Patients with Esophagus Cancer[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(11): 174-178.
杨爱娣, 向锋, 杨丽娜, 等. 十全大补汤合五味消毒饮加减对食管癌术后气血亏虚证患者免疫功能的影响[J]. 中国实验方剂学杂志, 2016,22(11):174-178. DOI： 10.13422/j.cnki.syfjx.2016110174.

YANG Ai-di, XIANG Feng, YANG Li-na, et al. Effect of Shiquan Dabu Tang Combined with Wuwei Xiaodu Yin on Immune Functions in Postoperative Qi and Blood Deficiency Patients with Esophagus Cancer[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(11): 174-178. DOI： 10.13422/j.cnki.syfjx.2016110174.

摘要

目的: 探讨十全大补汤合五味消毒饮加减对食管癌术后气血亏虚证患者免疫功能、生活质量的影响。方法: 本组研究共选择符合条件的病例90例

随机分为治疗组(46例)和对照组(44例);对照组于术后第2~9天采用肠内营养支持疗法;治疗组在对照组基础上给予十全大补汤合五味消毒饮加减辅助治疗;比较两组中医临床症状积分;检测两组血清CD4+和CD8+及免疫球蛋白(Ig)A

IgG

IgM水平;比较两组生活质量核心量表(EORTC QLQ-C30)V3.0评分和食管癌补充模式表(QLQ-OES18)评分。结果: 治疗组患者术后10 d的中医症状各指标评分均显著低于对照组(P < 0.01);治疗组术后10 d患者CD4+

CD4+/CD8+

IgA

IgG

IgM均显著高于对照组

CD8+显著低于对照组(P < 0.01);治疗组术后10 d患者功能领域指标评分均显著高于对照组

而症状领域指标评分均显著低于对照组(P < 0.01);术后10 d

治疗组患者EORTC QLQ-OES18各项评分均显著低于对照组(P < 0.01)。结论: 在常规肠内营养治疗基础上

十全大补汤合五味消毒饮加减治疗食管癌术后患者

可显著改善患者中医症状和生活质量

提高免疫功能。

Abstract

Objective: To observe the effects of Shiquan Dabu Tang combined with Wuwei Xiaodu Yin on immune function and living quality in postoperative Qi and blood deficiency patients with esophagus cancer. Method: Ninety eligible patients were selected in this study and randomly divided into control group (44 cases) and treatment group (46 cases). Patients in control group received enteral nutrition supporting therapy on postoperative day 2 to day 9. Patients in treatment group were treated with Shiquan Dabu Tang combined with Wuwei Xiaodu Yin based on the treatment in control group. Symptom scores of traditional Chinese medicine (TCM) were compared between two groups. Levels of serum CD4+

CD8+

IgA

IgG and IgM were detected in serum of two groups. Quality of Life Questionary-Core 30 (EORTC QLQ-C30) V3.0 scores and Esophageal Cancer Supplementary Schema Table (QLQ-OES18) scores were compared between two groups. Result: The TCM symptom scores in treatment group were significantly lower than those in control group on postoperative day 10(P < 0.01)

CD4+

CD4+/CD8+

IgA

IgG and IgM levels in treatment group were significantly higher than those in control group on postoperative day 10

while CD8+ level was significantly lower than that in control group(P < 0.01)

scores of functional area indexes in treatment group were significantly higher than those of control group

while scores of symptom area indexes in treatment group were significantly lower than those of control group(P < 0.01)

on postoperative day 10

scores of EORTC QLQ-OES18 in treatment group were significantly lower than those of control group with statistical differences (P < 0.01). Conclusion: Based on enteral nutrition supporting therapy

Shiquan Dabu Tang combined with Wuwei Xiaodu Yin in treatment of postoperative esophagus cancer with deficiency of Qi and blood could improve TCM symptoms and quality of life

and increase immune function.

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