Objective: To systematically review the efficacy and safety of Kudiezi injection in the treatment of unstable angina pectoris. Method: VIP

CBM

CNKI

Wanfang and PubMed were searched to find the clinical randomized controlled trials on Kudiezi injection treatment for unstable angina. The literature were screened according to inclusion and exclusion criteria

and evaluated according to Jadad quality assessment criteria;Revman 5.3 software was used for Meta-analysis. Result: A total of 10 randomized controlled trials were included in the systematic review

all of which were low-quality studies with Jadad score < 3 points. Meta analysis showed that Kudiezi injection was better than the control group in total effective rate [OR=3.31

95%CI(2.23

4.92)

P < 0.000 01]

markedly effective rate [OR=1.67

95%CI(1.28

2.18)

P=0.000 1] and electrocardiogram efficacy [OR=2.70

95%CI(1.95

3.74)

P < 0.000 01] for the treatment of unstable angina pectoris

with statistically significant differences. Conclusion: Kudiezi injection in the treatment of unstable angina can significantly improve the total effective rate

markedly effective rate and electrocardiogram efficacy with satisfactory safety. However

the existing small-sample randomized controlled trials are of low methodological and reporting quality

so large-sample high-quality clinical studies are required for further verification.