Objective: To evaluate the clinical efficacy of Xiyanping combined with ribavirin in the treatment of children with hand-foot-mouth disease. Method: Pubmed

Embase

Cochrane library

CNKI

CBM

WanFang Data and VIP were searched for randomized clinical trials (RCT) on Xiyanping combined with ribavirin in the treatment of children with hand-foot-mouth disease. Two independent reviewers strictly evaluated the quality of the included studies and extracted the data

then Meta-analysis was done by using RevMan 5.3 software. Result: Eventually 62 RCT involving a total of 8 945 children were included in the study. Meta-analysis results showed that there was statistically significant difference in total effective rate

antifebrile time

herpes fading time

recovery time of erythra in hands and feet

healing time of oral ulcer

cure time and hospital stay between Xiyanping combined with ribavirin group and control group in the treatment of children with hand-foot-mouth disease (P < 0.05). Conclusion: Xiyanping combined with ribavirin had certain effect in the treatment of children with hand-foot-mouth disease

but the quality of existing studies is poor

so more rigorous high quality multi-center randomized double-blind clinical studies are required for verification.