Irritable bowel syndrome (IBS) is a common functional intestinal disease

with abdominal pain or discomfort associated with bowel habit change as the main clinical manifestation

and its etiology has not been fully clear yet. Brain-gut Peptides with dual functions of transmitters or modulators for hormones and nerves

such as corticotrophin releasing factor (CRF)

substance P (SP)

motilin (MTL)

vasoactive intestinal peptide (VIP)

calcitonin gene-related peptide (CGRP)

nerve peptide Y (NPY) and somatostatin(SS)

play an important role in the pathogenesis of IBS. In vivo brain-gut peptide levels in IBS patients can reflect their disease progression from a certain extent. Chinese medicine interventions can regulate the abnormal changes of brain-gut peptides

thereby improve the symptoms. This review was written based on the brain-gut peptide changes of IBS patients and experimental animals as well as the effects of traditional Chinese medicine interventions

to provide ideas for the research on traditional Chinese medicine prevention and treatment of IBS.