Objective: To establish a relationship between micromeritic properties of Crataegi Folium blended powder and its compactibility. Method: Taking 50% ethanol extract powder of Crataegi Folium as a model drug

blended powder of Crataegi Folium were obtained by three kinds of drying technology and mixed with microcrystalline cellulose (MCC) and soluble starch at mass ratio of 1:0.5

1:1 and 1:2

respectively. The compactibility of blended powder was evaluated by monitoring the slope k in regression equation of tensile strength-pressure. Effect of micromeritic properties on compactibility was analyzed by stepwise regression analysis. Result: It was suggested from data of stepwise regression that compactibility was positively correlated to tap density (ρt)

cumulative pore volume (PV)

moisture content (MC) and critical relative humidity (CRH)

and negatively correlated with D50

particle distance (Span)

bulk density (ρb)

Carr index (CI)

Hausner ratio (HR)

specific surface area (SSA). Conclusion: Span

ρb

ρt

MC and CRH are proved as the key micromeritic properties involving in compactibility of Crataegi Folium blended powder.