Objective: To observe Qingfei Huoxue methods on serum interleukin (IL)-6

serum interleukin (IL)-8

tumor necrosis factor (TNF)-α

serum high sensitivity (hs-CRP) and plasma fibrinogen (Fg) and exhaled nitric oxide (FeNO) of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD)

so as to study the efficacy on AECOPD. Method: Totally 64 cases of AECOPD patients was randomly divided into control and treatment groups. Control group was given routine western medicine therapy

while treatment group was provided Qindan decoction in addition to the routine western medicine therapy. Their clinical effects and changes in serum IL-6

and IL-8

and TNF-α

and hs-CRP

and ESR and the plasma Fg and FeNO levels before and after the treatment were observed. Result: Efficiency of the treatment group was 90.63% (29/32)

which was higher than 71.88% (23/32) in the control group (P<0.05)

before the treatment

patients of both groups showed no statistically significant difference in IL-6

IL-8

TNF-α

hs-CRP

ESR and Fg and FeNO levels in plasma

after the treatment

the two groups showed no significant change in IL-6 and ESR

with no statistically significant difference

but significant changes in IL-8

TNF-α

hs-CRP and plasma Fg and FeNO levels (P<0.05); however

the treatment group was significantly inferior to the control group (P<0.05). Conclusion: Qindan decoction has a certain effect in regulating inflammatory responses of patients with AECOPD and reducing their serum IL-8

TNF-α

hs-CRP and plasma Fg

FeNO levels.