Objective: To investigate the clinical efficacy of double dose glucosidorum tripterygll totorum combined with ambrette capsule in the treatment of diabetic nephropathy (DN) and observe its effect on the level of inflammatory factors. Method: The 126 patients with DN were divided into control group (with ambrette capsules alone) and observation group (double dose glucosidorum tripterygll totorum combined with ambrette capsules). 8 weeks were regarded as one course of treatment. Before and after the treatment

the inflammatory indexes in serum[interleukin (IL)-18

IL-6

hypersensitive C-reactive protein(Hs-CRP)]

liver and kidney function

24 h urinary protein. Result: The total effective rate in the observation group was significantly higher than that in the control group

with significant difference between two groups(P<0.05). After treatment

urinary protein was significantly decreased

renal function improved

plasma albumin increased

Hs-CRP

IL-18 and IL-6 significantly decreased in both groups (P<0.01). The observation group was significantly better than the control group in the comparison of above indexes (P<0.01). No liver function damage was seen. Conclusion: Double dose glucosidorum tripterygll totorum combined with ambrette capsules can reduce the inflammation indexes in serum

and improve the clinical efficacy of DN.