Objective: To discuss the clinical efficacy of Fufang Changpu Yizhi decoction for mild cognitive impairment (MCI) with phlegm turbidity and stasis syndrome after stroke and investigate its effects on oxidative damage

blood lipid and cerebral blood flow. Method: One hundred and ninety-two eligible patients were randomly divided into control group (96 cases) and observation group (96 cases) by random number table. Patients in the control group received nimodipine tablets by orally taking

30 mg/time

1 time/day

patients in the observation group took Fufang Changpu Yizhi decoction orally

1 dose/day. The treatment course was 12 weeks for both groups. Before and after treatment

cognitive function was evaluated by mini mental state examination (MMSE) and montreal cognitive assessment (MoCA) scales. Scores of phlegm turbidity and stasis

as well as damage of brain collateral by toxin were graded; levels of superoxide dismutase (SOD)

malondialdehyde (MDA)

homocysteine (Hcy)

hemorheology indexes and blood lipid levels were detected. The mean blood flow rates of anterior cerebral artery (ACA) and middle cerebral artery (MCA) were measured once respectively before and after treatment. Result: The total effective rate of cognitive function was 79.17% in observation group

higher than 56.25% in control group (P<0.05). After treatment

scores of MoCA and MMSE in observation group were higher than those in control group

and scores of phlegm turbidity and stasis and damage of brain collateral were lower than those in control group (P<0.01). The levels of total cholesterol(TC)

triglyceride(TG) and low density lipoprotein cholesterin(LDL-C) in the observation group were lower than those in control group after treatment (P<0.05)

while the level of high density lipoprotein cholesterin(HDL-C) was lower than that in control group (P<0.05). Hemorheological indexes of whole blood viscosity (high shear and low shear)

plasma viscosity

fibrinogen and platelet aggregation rate in the observation group were lower than those in control group after treatment (P<0.05

P<0.01). Levels of Hcy and MDA in the observation group were lower than those in control group after treatment

while the level of SOD was higher than that in control group (P<0.05

P<0.01). Mean blood flow rates of ACA and MCA in treatment were higher than those in control group after treatment (P<0.01). Conclusion: Fufang Changpu Yizhi decoction has better effect than nimodipine tablets in improving the cognitive function of patients after stroke and ameliorating clinical symptoms

in addition

it can improve functions of vascular endothelium and blood circulation

regulate lipid metabolism

and promote cerebral hemodynamics.