Objective: To systematically evaluate the efficacy and safety of Tanreqing injection in treatment of respiratory infections in children. Method: Randomized controlled trials for Tanreqing injection in treatment of respiratory tract infections in children from 2005 to 2015 were searched in VIP

CBM

Wanfang Data

CNKI and Pubmed. In accordance with the inclusion/exclusion standards

efforts were made to select literatures

evaluate the quality of included studies

extract data

and then conduct Meta-analysis by using Revmen 5.3 software. Result: Totally 12 randomized controlled trials were included in the systematic evaluation

all of which were low-quality study with Jadad score of less than 3. The meta results showed that compared with the control group

Tanreqing injection in treatment of children's upper respiratory tract infection can improve clinical total efficiency [OR=6.42

95% CI (4.32

9.53)

P<0.000 01]

shorten the duration of fever [MD=-1.93

95% CI (-3.22

-0.65)

P=0.003]

relieve children's throat congestion [OR=12.79

95% CI (5.23

31.31)

P<0.000 01]and swollen tonsils [OR=2.98

95% CI (1.43

6.23)

P=0.004]

with statistically significant differences; but in terms of shortening the cough length [MD=-1.47

95% CI (-2.93

-0.01)

P=0.05]

there was no statistically significant difference from the control group. Conclusion: Tanreqing injection in treatment of respiratory tract infections in children has a better clinical efficacy and high safety. However

the existing studies have a low evidence level

so more large-sample

high-quality

multi-center randomized controlled trials shall be conducted for further verification.