Objective: To optimize percolation technology of Gubi Zhitong liquor and to provide a reference for industrial production of this preparation. Method: Taking composite score of extracting amounts of imperatorin

ferulic acid

cinnamaldehyde and dry extract yield as index

orthogonal test was adopted to optimize percolation technology with powder fineness

soaking time

percolation speed and liquor amount.HPLC was employed to determine contents of imperatorin

ferulic acid and cinnamaldehyde with detection wavelengths of 254

320

290 nm and mobile phases of methanol-water (60:40)

methanol-1% glacial acetic acid solution (30:70) and methanol-water (35:65). Result: Optimal percolation technology was as follows:powder fineness of 50 mesh

soaked 24 h with 10 times the amount of liquor

percolation speed of 2 mL·min-1.Under these conditions

extracting amounts of imperatorin

ferulic acid

cinnamaldehyde were 69.888

171.840

123.845 μg·g-1

dry extract yield was 32.16%. Conclusion: This optimized percolation process is simple and stable with good repeatability

it can provide a theoretical basis for further developing of Gubi Zhitong liquor.