Objective: To compare the contents of total alkaloids

sipeimine

sipeimine-3β-D-glucoside

adenosine and thymidine in Fritillariae Pallidiflorae Bulbus from different producing areas in Xinjiang

in order to identify the optimal growth area by principal component analysis and cluster analysis. Method: The five ingredients in Fritillariae Pallidiflorae Bulbus from different producing areas were measured by acid dye colorimetric method

high performance liquid chromatography(HPLC) and ultra performance liquid chromatography-evaporative light scattering detector(UPLC-ELSD). Data analysis was performed by SPSS 19.0. Result: The contents in Fritillariae Pallidiflorae Bulbus varied greatly in different producing areas

but similar in the same producing area. The scores and ranks of principal components were higher in Jimusaer County

Mulei County

Qitai County

Guozigou of Huocheng County

Sayram Lake of Yili and Wenquan County in Xinjiang. The scores and ranks of principal components were lower in Xinyuan County. Conclusion: Jimusaer County

Mulei County

Qitai County

Guozigou of Huocheng County

Sayram Lake of Yili and Wenquan County are the optimal producing areas of Fritillariae Pallidiflorae Bulbus. Meanwhile

temperature

moisture

light and soil in different producing areas have impacts on the content of ingredient

and so shall be taken into full account in selecting producing areas of Fritillariae Pallidiflorae Bulbus.