Objective: To investigate clinical efficacy of Manwei San in treating stomach Yin deficiency syndrome of chronic atrophic gastritis(CAG) and its influence on serum levels of Proteinase Ⅰ(PGⅠ) and gastrin(GS). Method: One hundred ten CAG cases were were randomly divided into observation group(55 cases) and control group (55 cases) referring to random number table.Cases in control group received Vitacoenzyme tablets 0.2 g (4 tablets/time

tid).Patients in observation group was treated with Manwei san

and Chinese herbal medicines were smashed and orally took with water(9 g/time

tid).Course of treatment was for 3 months for all cases.Scores of symptoms of traditional Chinese medicine(TCM) and pathology scores of gastric mucosa were compared between both groups pre-post treatment

and clinical efficacy was analysed after treatment.Serum levels of PGⅠand GS were detected in two groups before and after treatment. Result: Scores of TCM in observation group were obviously lower than those of control group(P < 0.01).The total efficacy of observation group was 90.74%

and control group was 75.93%with statistical difference between both groups (P < 0.05).After treatment

scores of inflammation of the mucosa

inflammation activity

reducing of gland

and intestinal metaplasia were remarkably lower than control group(P < 0.01).Compared to control group

serum levels of PGⅠand GS in observation group was obviously increased with statistical difference after treatment(P < 0.01). Conclusion: Manwei san could evidently improve clinical symptoms and signs

pathology scores of gastric mucosa

and clinical efficacy in treating stomach Yin deficiency syndrome of CAG

and its action may be related with elevating PGⅠand GS content in serum.