Objective: Fuzzy comprehensive evaluation method was used to evaluate subjective and objective indexes of Qingjiang orally disintegrating tablets at the same time for optimization of its formulation. Method: In order to optimize the amount of disintegrants and flavoring agent

central composite design was used

and the subjective indexes (degree of sweet and sour

gravel sense) and objective index (disintegration time) of Qingjiang orally disintegrating tablets were evaluated at the same time. Result: Optimal formulation of Qingjiang orally disintegrating tablets was Qingjiang taste-masking powder of 2 g

microcrystalline cellulose (MCC) of 1.472 g

low-substituted hydroxypropyl cellulose (L-HPC) of 0.398 g

crospolyvinylpyrrolidone (PVPP) of 0.252 g

flavoring agent of 0.301 g

lubricant of 0.06 g.Qingjiang orally disintegrating tablets had a good favor without gravel sense

disintegration time was only 48.8 s. Conclusion: Fuzzy comprehensive evaluation method can evaluate the subjective and objective indexes at the same time

and its results have good accuracy and repeatability.