Objective: To observe the effects of Yougui capsule on osteoporosis in ovariectomized rats. Method: A total of 105 SPF-grade SD rats were selected

in which 15 were used in the sham-operated group

and the remaining were ovariectomized to reproduce the model of osteoporosis. The ovariectomized rats were divided into model group

Yougui capsule low

medium and high-dose groups (0.71

1.43

2.85 g · kg-1)

estrogen group (diethylstilbestrol

0.02 mg · kg-1) and Xianling Gubao capsule group (0.25 g · kg-1)

with 15 rats in each group. The rats were given the corresponding drugs on the 7th day after surgery for six months. Orbital blood in rats was collected to determine Ca

P

alkaline phosphatase(ALP)

acid phosphatase(ACP) in serum. Right and left thighbones of the rats were collected to determine bone mineral density(BMD)

bone mineral(BMC) with dual energy X-ray absorptiometry. WDW electronic universal testing machine was used to determine mechanical performance indexes of the right thighbone

such as deflection

maximum force and bending strength. Result: Compared with the sham-operated group

the model group showed significant increases in Ca

P

ALP

ACP levels in serum

and decreases in BMD

BMC and bone biomechanical indexes(P<0.05

P<0.01); compared with the model group

Yougui capsule groups can significantly decrease Ca

P

ALP

ACP level in serum

and increase BMD

BMC and bone biomechanical indexes(P<0.05

P<0.01). Conclusion: Yougui capsule can improve biomechanical indexes of ovariectomized rats

and delay the rat bone mass loss

suggesting that Yougui capsule has the preventive effect on osteoporosis.