Objective: To investigate the effects of Tongyang Kuanxiong granule on coronary microcirculation improvement in the rat with coronary arteriosclerosis

and to explore the efficacy of the combined treatment of traditional Chinese and Western medicine for cardiovascular diseases. Method: Totally 50 Wistar rats were randomly divided into normal group

model group

Tongyang Kuanxiong granule group (50 mg · kg-1 · d-1)

Simvastatin group (5 mg · kg-1 · d-1)

and the mix treatment group (TY+simvastin). All the rats except those in normal group were used to prepare arteriosclerosis models. The rats in normal group were given with normal diet

and the rats in model group and treatment groups were given with high-fat diet and Vitamin D3 by ip. After 4 weeks of such feeding

the rats were treated for 8 weeks by intragastric administration. The expression levels of total cholesterol (TC)

triglyceride (TG) and low density lipoprotein (LDL-C) in serum were detected by enzyme-linked immunosorbent assay (ELISA). Artery plaque area was analyzed. Aorta was taken for immunohistochemistry and Western blot to detect the expression levels of interleukin (IL)-17A

vascular cell adhesion molecule-1(VCAM)-1 and intercelluar adhesion molecule-1 (ICAM)-1. Result: As compared with the normal group

the serum artery plaque area

expression levels of TC

TG

LDL-C were significantly increased in rats of model group(P<0.05). As compared with the model group

the expression levels of TC

TG

LDL-C levels

and artery plaque area were significantly reduced in treatment groups (P<0.05

P<0.01). As compared with Tongyang Kuanxiong granule group

the improvement effect was more obvious in mixed treatment group (P<0.05). As compared with model group

the expression levels IL-17A

VCAM-1 and ICAM-1 in coronary atherosclerosis tissues were decreased in treatment groups(P<0.05)

and the efficacy of mixed treatment group was better than that of Tongyang Kuanxiong granule alone group. Conclusion: Tongyang Kuanxiong granules can relieve tissue inflammation and treat coronary atherosclerotic diseases by improving blood lipid indexes

reducing the expression levels of IL-17A

VCAM-1

ICAM-1

and reducing artery plaque area

so the integrated Chinese and western medicine treatment is worthy for further promotion.