Objective: To compare and systematically evaluate Tianma preparation and conventional antihypertensive western medicine in clinical efficacy and safety in the treatment of essential hypertension. Method: Systematic literature searches were perform in Cochrane library

PubMed

EMBase

CBM

CNKI

VIP database

Wanfang database and CDMD from Jan 1979 to July 2015.The quality evaluation of the included studies and data extraction were performed by using Cochrane system. The Meta-analysis was performed by using Revman 5.3.5 software. Result: A total of 27 studies involving 2 674 patients were included. The results of Meta-analysis showed that: as compared with conventional western medicine group

the antihypertensive effects and efficacy of traditional Chinese medicine syndromes were more obvious in Tianma preparation group [OR=1.67

95%CI(1.14

2.46)

P=0.009<0.05]and [OR=3.65

95% CI (2.42

5.51)

P<0.000 01]respectively. The safety evaluation results showed that: there was statistically significant difference in adverse reaction rate [RR=0.36

95% CI (0.23

0.56)

P<0.000 01]. Conclusion: Tianma preparation has very good clinical efficacy and safety for the treatment of essential hypertension

but the quality of included studies is low

so it also needs further in-deep research.