As a kind of endogenous non-coding RNA with regulation and control function

microRNA widely participates in human development

cell proliferation and lipid metabolism processes

and also plays a regulatory role in most of the life processes. In recent years

the scholars believe that vascular dementia (VD) may have a close relationship with lack of acetylcholine

brain cells apoptosis

synaptic change after cerebral ischemia and inflammation caused by cerebral ischemia. In addition

microRNA actively participates in the occurrence and development of the above-mentioned risk factors of VD

so microRNA may play a vital role in the occurrence and development of the disease. With the gradual in-depth research on the regulation mechanism of microRNA in life processes in the body

numerous studies have confirmed that microRNA expression in circulation of blood has specific changes in patients with prostate cancer

breast cancer and femoral head necrosis. As a potential new disease marker

the circulating microRNA has been recognized by a large number of scholars

and the research of circulating microRNA change in the body is supposed to be used for early diagnosis of the disease. Research progress of microRNA related to VD is reviewed in this paper

and at the same time

the effect of microRNA for early diagnosis and treatment of vascular dementia is also discussed.