补阳还五汤血浆指纹图谱的建立

黄海艳; 祝赫; 韩彬; 张继平; 李蕾

doi:10.13422/j.cnki.syfjx.2016150096

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补阳还五汤血浆指纹图谱的建立

药物代谢 | 更新时间：2024-09-23

- 补阳还五汤血浆指纹图谱的建立
- Estblish Fingerprint of Medicated Plasma of Buyanghuanwu Tang
- 中国实验方剂学杂志 2016年22卷第15期页码：96-99
- 作者机构：
- 作者简介：
- 基金信息：
  
  广东省自然科学基金项目（S2013010012284）;广东省中医药局建设中医药强省立项资助科研课题（2009055，20111058）
- DOI：10.13422/j.cnki.syfjx.2016150096
  中图分类号： R285.5
- 纸质出版日期：2016
- 稿件说明：
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黄海艳, 祝赫, 韩彬, 等. 补阳还五汤血浆指纹图谱的建立[J]. 中国实验方剂学杂志, 2016,22(15):96-99.

HUANG Hai-yan, ZHU He, HAN Bin, et al. Estblish Fingerprint of Medicated Plasma of Buyanghuanwu Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 96-99.
黄海艳, 祝赫, 韩彬, 等. 补阳还五汤血浆指纹图谱的建立[J]. 中国实验方剂学杂志, 2016,22(15):96-99. DOI： 10.13422/j.cnki.syfjx.2016150096.

HUANG Hai-yan, ZHU He, HAN Bin, et al. Estblish Fingerprint of Medicated Plasma of Buyanghuanwu Tang[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(15): 96-99. DOI： 10.13422/j.cnki.syfjx.2016150096.

摘要

目的：建立补阳还五汤含药血浆指纹图谱，探讨补阳还五汤在大鼠体内的药效物质基础。方法：通过比较补阳还五汤水煎液、补阳还五汤水煎液含药血浆、空白血浆HPLC指纹图谱，推断大鼠口服补阳还五汤水煎液后，血浆中的原型成分及代谢产物。结果：口服补阳还五汤水煎液后，在大鼠血浆中发现了30个入血成分，其中10个为血浆固有成分，1个为溶剂峰，19个为药源性成分，其中4个为药材原型成分，15个为代谢产物，其中2个为黄芪代谢产物，1个为桃仁代谢产物。结论：该研究建立的方法准确、可靠，可用于补阳还五汤水煎液血浆指纹图谱和药效物质基础的研究。

Abstract

Objective: In order to establish the plasma HPLC fingerprints of Buyanghuanwu Tang(BYHWT) and to further explore its pharmacodynamic material basis. Method: The prototype components and metabolites in rat plasma were identified through comparing the fingerprints of BYHWT

rat plasma-containing active components and blank plasma. Result: After the ig administration of BYHWT

30 main components into blood were marked in the plasma fingerprint

10 came from the original compound of rat plasma

one peak was the solvent peak. Other 19 were the drug-induced compositions

4 of which were prototype constituents

other 15 were metabolites

such as 2 metabolites from Astragali Radix

1 metabolite from Semen Persicae. Conclusion: The method established in this study was accurate

reliable

and can be used to research the BYHWT plasma fingerprint and efficacy material foundation.

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