Objective: To evaluate the efficacy and safety of combined treatment of Wenxin granules and bisoprolol in treating arrhythmias induced by heart failure (HF). Method: Literatures were searched in PubMed

EMbase

CNKI

Cochrane Central Register of Controlled Trials

Wanfang and VIP database (since the establishment to May 10

2015) to select qualified RCTs. RevMan 5.3 software was used to make a Meta-analysis. Result: Totally 279 relevant literatures

involving 6 RCTs (527 patients)

were selected and included in this study. According to the results of the meta-analysis

the cardiac failure-arrhythmias group showed a higher rate in improving arrhythmia frequency than the control group [OR=3.85

95%CI (2.39

6.20)

P<0.000 01]

and in improving palpitations than the control group [OR=4.48

95%CI (2.42

8.30)

P<0.000 01]. The combined treatment group (Wenxin granules + bisoprolol) showed a lower rate of adverse events than the control group [OR 0.42

95%CI (0.18

1.01)

P<0.05]. Conclusion: Combined treatment with Wenxin granules and bisoprolol is more effective and causing less adverse events than the use of only bisoprolol for treating HF-induced ventricular arrhythmias.