Objective: To investigate the clinical efficacy of Tongshen decoction combined with traditional Chinese medicine(TCM) moxibustion mud in treating myospasm of ischemic stroke recovery period with Qi deficiency and blood stasis syndrome

and its influence on serum levels of glycine (Gly) and gamma amino acid butyric acid (GABA). Method: Eighty-nine eligible cases were selected and randomly divided into control group and observation group according to random number table. Conventional interventions were made to the two groups according to 'Chinese Stroke Rehabilitation Treatment Guidelines'. The control group (44 cases) was treated with comprehensive rehabilitation therapy. The treatment group (45 cases) was given Tongshen decoction by oral (1 dose/day

bid)

traditional Chinese medicine cerate on the corresponding acupuncture points and warming with infrared physiotherapy machine (1 h/time

qd). All patients were treated for 6 weeks. Clinic Spasticity Index (CSI)

modified Ashworth score

Barthel index (BI) score

walking ability and TCM symptom scores were compared between the two groups. Clinical efficacies were analyzed between the two groups. Their adverse events were observed. Serum levels of Gly and GABA were detected in the two groups. Result: Total effective rate of observation group was 93.33%

which was higher than 75%of control group (P<0.05). CSI

Ashworth

walking ability and TCM symptom scores in observation group were obviously lower

but with a higher BI score (P<0.01). Adverse events of observation group was 6.67%

which was evidently lower than 25%of control one (P<0.01). After treatment

serum levels of Gly and GABA in observation group were obviously higher than control group

with statistical significance (P<0.01). Conclusion: Tongshen decoction combined with TCM moxibustion mud has an exact effect in treating myospasm of ischemic stroke recovery period with Qi deficiency and blood stasis syndrome

which may be related to up-regulation of serum levels of Gly and GABA.