Objective: To observe the curative effect of Weining tea bag and omeprazole in treatment of liver and stomach disharmony reflux esophagitis. Method: The 64 cases of liver and stomach disharmony reflux esophagitis were randomly divided into treatment group (32 cases) and control group (32 cases). The patients in both groups took omeprazole as the basis treatment

and patients in treatment group received additional Weining tea bag while patients in control group received additional Mosapride dispersible tablets

4 weeks as a course of treatment

and both groups were treated for 1 course of treatment. The clinical symptom scores

degree of endoscopic esophageal inflammation

bile reflux

plasma motilin and prostaglandin E2 levels were observed before and after treatment. Result: The endoscopic scores after treatment were significantly reduced in both groups (P<0.05)

treatment group was superior to the control group in efficacy on endoscopic esophageal inflammation (P<0.05). The symptom scores were significantly reduced in both groups after treatment (P<0.05

P<0.01)

and the effect in treatment group was better than that in control group (P<0.05). Treatment group was superior to control group in the syndrome efficacy (P<0.05). The increase in plasma motilin level in treatment group was superior to that in control group after treatment (P<0.05). The level of plasma prostaglandin was significantly increased in the treatment group after treatment (P<0.05). The disappearance rate of bile under gastroscope in treatment group was superior to that in control group after treatment (P<0.05). Conclusion: Weining tea bag is an effective Chinese medicine for liver and stomach disharmony reflux esophagitis

and the mechanism may be associated with increasing gastric motility

reducing bile reflux

and regulating gastrointestinal hormones.