Objective: To observe the curative effect of modified Yinjia pills in treating infertility due to chronic pelvic inflammation after laparoscopy

and the influence on inflammatory reaction and hemorheology. Method: One hundred and thirty-three patients were randomly divided into control group (65 cases) and observation group (68 cases) by random number table. Both groups received laparoscopic surgery. After the surgery

patients in control group received the levofloxacin hydrochloride tablets and metronidazole tablets for anti-infection. The courses of treatment were 14 days. In addition to the therapy of control group

patients in observation group were given modified Yinjia pills for 3 months. After two menstrual cycles

both groups could be put into the pregnancy test

and observed consecutively for six menstrual cycles. The follow-up visit shall last for three months after getting pregnant. Pregnancy rate and ectopic pregnancy rate were observed within 6 menstrual cycles. And before treatment

and 3 months later after the surgery

scores of damp heat and blood stasis were graded

and levels of tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6) and interleukin-10 (IL-10) and hemorheology were detected. Result: The pregnancy rate in observation group was 66.17%

which was superior to 47.69%in control group (P<0.05). And ectopic pregnancy rate in observation group was 2.22%

which was lower than 12.90%in control group

but no statistical significance between the two groups. Three months later after the surgery

score of damp heat and blood stasis and levels of TNF-α and IL-6 were lower than that in control group (P<0.01)

level of IL-10 was higher than in control group (P<0.01). And the whole blood viscosity (high and low cut)

plasma viscosity

fibrinogen and platelet aggregation rate in observation group were lower than those in control group (P<0.01). Conclusion: Modified Yinjia pills in treating infertility due to chronic pelvic inflammation after laparoscopy can improve pregnancy rate

and ameliorate symptoms on infertility due to chronic pelvic inflammation after laparoscopy

and its mechanism of action may be correlated to alleviation of inflammatory response and blood fluidity.