Objective: To compare protective effect of raw and processed products of Gardeniae Fructus on acute hepatic injury induced by CCl4 in rats. Method: SD rats were evenly randomized into 9 groups by weight

such as normal group

bifendate group (35 mg · kg-1)

model group

low and high dose of raw products of Gardeniae Fructus (2.0

1.0 g · kg-1) groups

low and high dose of fried products of Gardeniae Fructus (2.0

1.0 g · kg-1) groups

low and high dose of stir-baked products of Gardeniae Fructus (2.0

1.0 g · kg-1) groups.Twelve hours after modeling

serum levels of aspartate aminotransferase (AST)

alanine aminotransferase (ALT)

lactate dehydrogenase (LDH) and total protein (TP) were examined.Super oxide dismutase (SOD) activity and malondialdehyde (MDA) content in liver tissue were determined.Histopathological changes of liver were observed. Result: Compared with the normal group

the model group significantly increased levels of AST

ALT

LDH

MDA and decreased level of TP and SOD activity.Liver cells arranged disordered

swelling and necrosis of liver cells were obvious.Compared with the model group

levels of AST

ALT and LDH in serum of raw and processed products groups decreased significantly

the raw and fried products groups were better.Raw and processed products groups increased activity of SOD and decreased the level of MDA significantly.There were no significant difference between the model group and administration groups in serum TP level of rats.Each administration groups reduced the number of degeneration

necrosis of liver cells and improve inflammatory cells infiltration. Conclusion: The raw

fried and stir-baked products of Gardeniae Fructus have an effective protection on acute hepatic injury induced by CCl4

the the raw and fried products are better in reducing enzyme level and antioxidant capacity.The fried products can decrease the bitter and cold of raw products.So the fried products of Gardeniae Fructus may be more appropriate in clinical application.