Objective: To investigate the long-term clinical efficacy of lupus prescription on systemic lupus erythematosus (SLE)

and further clarify the composition rules of the prescription

explore and enrich the theory of SLE in traditional Chinese medicine treatment system. Method: Retrospective

multi center test method was used

and 300 active SLE patients were randomly divided into treatment group and control group

150 cases in each group. Patients in treatment group received hormone Prednison+Chinese herbal medicine lupus prescription

while patients in control group only received hormone therapy. The treatment was 6 months for both groups. Both groups were observed for changes of 24 h urine protein quantity

immune index

lupus activity scores before and after treatment

as well as the incidence of adverse effects

and the recurrence of the disease within half an year. Result: After treatment

the improvement of 24 h urinary protein

C4 and erythrocyte sedimentation rate (ESR) in treatment group was significantly better than that in control group (P<0.05). There was no significant difference in the improvement of the other indicators. The lupus activity scores in treatment group were significantly lower than those in control group (P<0.05). The incidence of side effects and recurrence rate of the disease in the treatment group were significantly lower than those in control group (P<0.05). Conclusion: Chinese herbal medicine lupus prescription has obvious long-term efficacy in treatment of SLE

especially in regulating immune function

promoting withdrawal of hormone

lessening the side effects of Western medicine and improving the therapeutic effect.