Objective: To observe the clinical efficacy of Zhuling Tang combined with Fuyuan Huoxue Tang in the treatment of severe closed renal injury and investigate its effects and clinical significance on serum interleukin (IL)-6

IL-8

IL-10 and tumor necrosis factor (TNF)-α levels in the course of treatment. Method: The 80 patients with severe closed renal injury were randomly divided into treatment group (40 cases) and control group (40 cases). Patients in control group received conventional western medicine treatment

and patients in treatment group orally took Zhuling Tang combined with Fuyuan Huoxue Tang based on the treatment in control group. The peripheral blood leukocytes

length of hospital stay

disappearance time of hematuria under microscope

beginning time of perirenal hematoma absorption and renal subcapsular hematoma absorption were observed. CT was taken in 2

4

12 weeks to observe the changes of perirenal hematoma

and the IL-6

IL-8

IL-10 and TNF-α expression levels were detected by enzyme-linked immunosorbent assay (ELISA) in 0.5

1

2

3

5

7 d. Result: After treatment

the length of hospital stay

beginning time of perirenal hematoma absorption and renal subcapsular hematoma absorption

and disappearance time of hematuria under microscope in treatment group were significantly shorter than those in control group (P< 0.05)

the declined number of white blood cells in peripheral blood was significantly higher than that in control group (P< 0.01)

and the increased number of hemoglobin in peripheral blood was significantly superior to that in control group (P<0.01). At 2

4 and 12 weeks after treatment

the absorption of perirenal hematoma in treatment group was significantly better than that of control group (P<0.01). The levels of IL-6

IL-8 and TNF-α in treatment group were significantly lower than those in control group in earlier periods (P<0.01)

and the level of IL-10 in the treatment group was significantly higher than that in control group in earlier periods (P<0.01). Conclusion: Zhuling Tang combined with Fuyuan Huoxue Tang has obvious clinical efficacy in the treatment of closed renal injury

which can reduce the production of proinflammatory cytokines IL-6

IL-8 and TNF-α

promote the production of anti-inflammatory factor IL-10

and inhibit the inflammatory reaction of the patients. Therefore

its mechanism may be associated with regulating the cytokines and inhibiting inflammatory reaction.