正交试验优选甘草制款冬花的炮制减毒工艺

李明晓; 周臻; 田素英; 林剑峰

doi:10.13422/j.cnki.syfjx.2016180017

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正交试验优选甘草制款冬花的炮制减毒工艺

药剂与炮制 | 更新时间：2024-01-04

- 正交试验优选甘草制款冬花的炮制减毒工艺
- Optimization of Toxicity Attenuation Processing Technology for Farfarae Flos Being Processed with Glycyrrhizae Radix et Rhizoma by Orthogonal Test
- 中国实验方剂学杂志 2016年22卷第18期页码：17-20
- 作者机构：
- 作者简介：
- 基金信息：
  
  广东药学院大学生创新创业训练计划项目（201410573004）
- DOI：10.13422/j.cnki.syfjx.2016180017
  中图分类号： R283
- 纸质出版日期：2016
- 稿件说明：
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李明晓, 周臻, 田素英, 等. 正交试验优选甘草制款冬花的炮制减毒工艺[J]. 中国实验方剂学杂志, 2016,22(18):17-20.

LI Ming-xiao, ZHOU Zhen, TIAN Su-ying, et al. Optimization of Toxicity Attenuation Processing Technology for Farfarae Flos Being Processed with Glycyrrhizae Radix et Rhizoma by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(18): 17-20.
李明晓, 周臻, 田素英, 等. 正交试验优选甘草制款冬花的炮制减毒工艺[J]. 中国实验方剂学杂志, 2016,22(18):17-20. DOI： 10.13422/j.cnki.syfjx.2016180017.

LI Ming-xiao, ZHOU Zhen, TIAN Su-ying, et al. Optimization of Toxicity Attenuation Processing Technology for Farfarae Flos Being Processed with Glycyrrhizae Radix et Rhizoma by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(18): 17-20. DOI： 10.13422/j.cnki.syfjx.2016180017.

摘要

目的：优选甘草制款冬花的炮制减毒工艺，为款冬花的炮制生产工艺提供参考。方法：以总生物碱含量为指标，甘草水煎煮次数、烘制温度及甘草用量（甘草质量/款冬花质量）为考察因素，采用正交试验对甘草制款冬花的减毒工艺进行优选，考察款冬花甘草制品中有效成分含量的变化。结果：款冬花甘草制最佳减毒工艺条件为甘草用量10%，水煎煮数3次，烘制温度90℃；甘草制款冬花中总生物碱、款冬酮及醇浸出物质量分数分别为0.080 3 mg·g-1，0.161%，26.31%。结论：与生品相比，款冬花甘草制品中总生物碱含量显著减少，款冬酮和醇浸出物含量增加。优选的款冬花甘草制减毒工艺稳定可行，提示甘草汁制款冬花有一定的合理性，具有实际应用意义。

Abstract

Objective: To optimize toxicity attenuation processing technology of Farfarae Flos being processed with Glycyrrhizae Radix et Rhizoma. Method: With the content of total alkaloids as index

toxicity attenuation processing technology of Farfarae Flos being processed with Glycyrrhizae Radix et Rhizoma was optimized by orthogonal test

and contents of alcohol-soluble extract and tussilagone in Farfarae Flos were determined before and after this optimized technology. Result: The best processing technology was as follows:adding 10% Glycyrrhizae Radix et Rhizoma

decocted three times

baking temperature at 90℃.Under these conditions

average content of total alkaloids was 0.080 3 mg·g-1

average content of tussilagone was 0.161%

average mass fraction of alcohol-soluble extract was 26.31%. Conclusion: After being processed

the content of total alkaloids in Farfarae Flos is decreased significantly

and contents of alcohol-soluble extract and tussilagone increase.This optimized processing technology is stable and feasible.This paper shows that Farfarae Flos being processed with Glycyrrhizae Radix et Rhizoma is rational.

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