益气解毒护心汤治疗邪毒侵心型急性病毒性心肌炎的疗效分析

刘灿君; 单洁; 温海涛; 黄侃

doi:10.13422/j.cnki.syfjx.2016180149

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益气解毒护心汤治疗邪毒侵心型急性病毒性心肌炎的疗效分析

临床 | 更新时间：2024-01-04

- 益气解毒护心汤治疗邪毒侵心型急性病毒性心肌炎的疗效分析
- Efficacy Analysis of Yiqi Jiedu Huxin Decoction on Acute Viral Myocarditis with Syndrome of Pathogenic Toxin Invasion Heart
- 中国实验方剂学杂志 2016年22卷第18期页码：149-153
- 作者机构：
- 作者简介：
- 基金信息：
  
  黑龙江省教育厅科学技术研究项目（12531818）
- DOI：10.13422/j.cnki.syfjx.2016180149
  中图分类号： R259
- 纸质出版日期：2016
- 稿件说明：
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刘灿君, 单洁, 温海涛, 等. 益气解毒护心汤治疗邪毒侵心型急性病毒性心肌炎的疗效分析[J]. 中国实验方剂学杂志, 2016,22(18):149-153.

LIU Can-jun, SHAN Jie, WENG Hai-tao, et al. Efficacy Analysis of Yiqi Jiedu Huxin Decoction on Acute Viral Myocarditis with Syndrome of Pathogenic Toxin Invasion Heart[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(18): 149-153.
刘灿君, 单洁, 温海涛, 等. 益气解毒护心汤治疗邪毒侵心型急性病毒性心肌炎的疗效分析[J]. 中国实验方剂学杂志, 2016,22(18):149-153. DOI： 10.13422/j.cnki.syfjx.2016180149.

LIU Can-jun, SHAN Jie, WENG Hai-tao, et al. Efficacy Analysis of Yiqi Jiedu Huxin Decoction on Acute Viral Myocarditis with Syndrome of Pathogenic Toxin Invasion Heart[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(18): 149-153. DOI： 10.13422/j.cnki.syfjx.2016180149.

摘要

目的：探讨益气解毒护心汤治疗急性病毒性心肌炎（VMC）邪毒侵心证的疗效以及对血清高迁移率蛋白1（HMGB1）和核转录因子-κB（NF-κB）水平的影响。方法：将152例VMC患者参照随机数字表法分为观察组和对照组，各76例。两组均给予卧床休息等非药物治疗。对照组口服维生素C，200 mg/次，3次/d；辅酶Q10，1片/次，3次/d。观察组在对照组的基础上给予益气解毒护心汤干预，1剂/d，常规水煎煮2次，分早晚内服。疗程均为4周。两组进行治疗前后中医症状评分；检测治疗前后血清肌酸激酶（CK），肌钙蛋白I（cTnI），肌酸激酶同工酶（CK-MB）水平；检测血清HMGB1和NF-κB水平。结果：观察组总有效率为92.11%，对照组为80.26%，观察组高于对照组（P<0.05）。治疗后观察组心悸、心烦胸闷、发热、咽痛评分低于对照组（P<0.01）。治疗后观察组CK，cTnI和CK-MB水平均显著低于对照组（P<0.01）；观察组在治疗后2，4周患者血清HMGB1和NF-κB水平分别低于对照组同期水平。结论：在西医常规干预的基础上，益气解毒护心汤治疗邪毒侵心型VMC可明显改善中医症状，降低心肌酶指标水平，提高临床疗效，其作用机制可能与下调患者血清HMGB1和NF-κB水平有关。

Abstract

Objective: To investigate the efficacy of Yiqi Jiedu Huxin decoction in treating acute viral myocarditis(VMC) with syndrome of pathogenic toxin invasion heart and observe its effects on levels of high mobility group box1 protein(HMGB1) and nuclear factor-κB(NF-κB). Method: The 152 cases of acute VMC were randomly divided into control group(76 cases) and observation group(76 cases) according to random number table. All patients were treated with non-drug treatment such as staying in bed. Cases in control group were orally treated with Vitamin C tablets(200 mg/time and tid) and Q10 Tablets(1 tablet/time

tid). Based on the treatment in control group

patients in treatment group were given with Yiqi Jiedu Huxin decoction

1 dose/d and bid. The treatment course was four weeks for both groups. Scores of traditional Chinese medicine(TCM) symptoms were graded before and after treatment

levels of creatine kinase(CK)

serum troponinI(cTnI)

creatine kinase-MB(CK-MB) were detected before and after treatment. Serum levels of HMGB1 and NF-κB were detected in two groups. Result: Total effective rate was 92.11% in observation group

higher than 80.26% in control group(P<0.05). After treatment

scores of palpitations

chest pain

fever

and sore throat in observation group were lower than those in control group(P<0.01)

the levels of CK

cTnI and CK-MB in observation group were significantly lower than those in control group(P<0.01). Serum levels of HMGB1 and NF-κB in observation group were lower than those in control group at week 2 and week 4 after treatment. Conclusion: Based on the conventional western medicine intervention

Yiqi Jiedu Huxin decoction in treating acute VMC with syndrome of pathogenic toxin invasion heart can obviously improve TCM symptoms

reduce the levels of myocardial enzyme

and increase clinical efficacy. Its mechanism may be associated with down-regulating serum levels of HMGB1 and NF-κB.

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