Objective: To investigate the clinical efficacy of compound Rhodiola A Bor oral solution combined with ambroxol hydrochloride treatment for patients with radioactive lung injury by comparing the application effect of compound Rhodiola A Bor oral solution combined with ambroxol hydrochloride treatment and simple ambroxol hydrochloride treatment. Method: The 116 patients with radioactive lung injury in our hospital from August 2014 to August 2015 were selected and randomly divided into observation group(58 cases) and control group(58 cases) by random number table. Patients of both groups received oral ambroxol hydrochloride tablets

and patients in observation group were also given with oral liquid of compound rhodiola A Bor oral solution based on this. The levels of transforming growth factor-β1(TGF-β1)

tumor necrosis factor-α(TNF-α)

and changes of Karnofsky(KPS) scores after radiation therapy

after 4 weeks and 8 weeks of treatment

as well as the changes in lung function and the quality of life before and after treatment were observed in both groups. Result: The levels of TGF-β1 and TNF-α of patients in observation group were significantly lower than those of control group after 4 weeks and 8 weeks treatment(P<0.05)

and the KPS scores in observation group were significantly higher than those of control group after 4 weeks and 8 weeks treatment (P<0.05). As compared with control group after treatment

the test results of vital capacity(VC)

forced vital capacity(FVC)

forced expiratory volume in one second(FEV1)

FEV1/FVC

the scores of functional areas and scores of overall health in observation group were significantly increased after treatment

while the scores of symptoms and scores of single items were significantly decreased(P<0.05). The total effective rate was 89.66%in observation group

and 60.34%in control group. As compared with the control group after treatment

the number of patients with marked effect and the total effective rate in observation group were significantly increased

and the number of patients with no effects was decreased significantly (P<0.05). Conclusion: The application of compound Rhodiola A Bor oral solution combined with ambroxol hydrochloride treatment for the radioactive lung injury can effectively reduce the levels of TGF-β1 and TNF-α caused by a radiation therapy

improve lung function

and thus improve the clinical efficacy

at the same time with a significant effect to the improvement of life ability and life quality.