Objective: To clarify material basis and mechanism of compound Danshen formulae

and provide a reference for clinical application of this compound. Method: Traditional Chinese medicine pharmacological database(TCMSP) was adopted

101 candidate compounds from compound Danshen formulae were screened

a molecular docking program of AutoDock Vina was employed to investigate the interactions of these 101 candidate compounds with eight coronary heart disease targets

namely angiotensin-Ⅰ converting enzyme(ACE)

hydroxymethylglutaryl coenzyme A receptor(HMGR)

human heat shock protein 90 kinase(HSP90)

peroxisome proliferator activated receptor-γ(PPAR-γ)

thrombin

vascular endothelial growth factor receptor-Ⅱ(VEGFR2)

androgen receptor(AR) and cyclooxygenase-2(COX-2). Result: Danshen-spiroketallactone can interact with six targets

seventeen compounds can interact with two or more targets

and the other five compounds may be potent for at least one of these eight targets. Conclusion: In this study

a preliminary explanation of compound Danshen formulae

Salviae Miltiorrhizae Radix et Rhizoma is a "monarch" medicine

Notoginseng Radix et Rhizoma and Borneolum Syntheticum are used as "minister" medicine and "assistant" medicine

respectively.It gives us a better understanding of the mechanism of this compound.