Objective: To optimize extraction process of Chaishao Changning granules. Method: Orthogonal design were used to optimize extraction process of Chaishao Changning granules by taking solvent volume

extraction time and times as factors

composite score among yield of dry extract

contents of paeoniflorin

berberine hrdrochloride and citric acid

intestinal propulsive rate and diarrhea index was index. Result: Optimum extraction process of Mume Fructus was:extracted twice with 10 times the amounts of water

1 h for per time;extracting amount of citric acid was 154.17 mg·g-1

yield of dry extract was 31.27%.Optimum extraction process of others herbs in Chaishao Changning granules was:extracted thrice with 10 times the amount of water

1 h for each time;extracting amounts of paeoniflorin and berberine hydrochloride were 3.97

0.66 mg·g-1

yield of dry extract was 26.36%

intestinal propulsive rate was 61.97%and diarrhea index was 0.98. Conclusion: These optimized processes are stable and feasible

which can provide reliable reference value for the actual production of Chaishao Changning granules.