Objective: To study the effect of Ershiwuwei Songshi pills on liver injury in rabbits with endotoxemia

and observe the morphological changes in liver tissues of rabbits. Method: Thirty rabbits were randomly divided into five groups:model group

Ershiwuwei Songshi pills high dose

middle dose and low dose groups (0.5

0.167

0.06 g·kg-1

n=6)

and dexamethasone group (0.005 g·kg-1)

n=6 in each group. The rabbits were treated with corresponding drugs once a day for continuous 5 days by ig administration; the rats in model group and dexamethasone group received the same volume of normal saline by ig administration. Endotoxemia was used to attack the rabbits before drug administration on day 5

and the death of rabbits in each group was compared in 12 h; body temperature

blood routine and liver function were examined

and pathological changes of liver tissues were also observed by htoxylin eosin(HE) staining in each group. Result: the content of total bilirubin an alanine aminotransferase(ALT) in serum can be reduced by high dose Ershiwuwei Songshi pills and liver pathological damage was significantly reduced; the content of aspartate aminotransferase(AST) in serum and numbers of WBC can be reduced by low dose of Ershiwuwei Songshi pills

with significant difference as compared with the model group (P<0.05). Conclusion: Ershiwuwei Songshi pills has a protective effect on liver injury of rabbits induced by endotoxin.