护肾通淋汤对肾结石ESWL术后肾损伤的保护作用

李表清; 房华; 彭国珍

doi:10.13422/j.cnki.syfjx.2016190140

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护肾通淋汤对肾结石ESWL术后肾损伤的保护作用

临床 | 更新时间：2024-01-04

- 护肾通淋汤对肾结石ESWL术后肾损伤的保护作用
- Protection Effect of Hushen Tonglin Decoction for Kidney Injury of Patients with Kidney Calculi After ESWL
- 中国实验方剂学杂志 2016年22卷第19期页码：140-143
- 作者机构：
- 作者简介：
- 基金信息：
  
  海南省自然科学基金项目（308978）
- DOI：10.13422/j.cnki.syfjx.2016190140
  中图分类号： R699.2
- 纸质出版日期：2016
- 稿件说明：
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李表清, 房华, 彭国珍. 护肾通淋汤对肾结石ESWL术后肾损伤的保护作用[J]. 中国实验方剂学杂志, 2016,22(19):140-143.

LI Biao-qing, FANG Hua, PENG Guo-zhen. Protection Effect of Hushen Tonglin Decoction for Kidney Injury of Patients with Kidney Calculi After ESWL[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(19): 140-143.
李表清, 房华, 彭国珍. 护肾通淋汤对肾结石ESWL术后肾损伤的保护作用[J]. 中国实验方剂学杂志, 2016,22(19):140-143. DOI： 10.13422/j.cnki.syfjx.2016190140.

LI Biao-qing, FANG Hua, PENG Guo-zhen. Protection Effect of Hushen Tonglin Decoction for Kidney Injury of Patients with Kidney Calculi After ESWL[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(19): 140-143. DOI： 10.13422/j.cnki.syfjx.2016190140.

摘要

目的：观察护肾通淋汤对肾结石体外冲击波碎石（ESWL）术后肾损伤的保护作用及对血清超氧化物歧化酶（SOD）和丙二醛（MDA）水平的影响。方法：128例肾结石患者随机分为对照组（63例）和观察组（65例）。两组均采用ESWL治疗，术后给予抗感染等对症处理，对照组口服排石颗粒，20 g/次，3次/d，连续服用14 d；观察组口服护肾通淋汤，1剂/d，连续服用14 d。记录腰痛减轻时间和肉眼血尿消失时间；于ESWL术后当天，7 d，14 d采取B超检测排石情况；于术后12 h，7 d，14 d检测SOD，MDA，β2微球蛋白（β2-MG），尿N-乙酰-β-氨基葡萄糖苷酶（NAG）和半胱氨酸蛋白酶抑制剂C（CysC）水平。结果：观察组有效率为93.85%，高于对照组的82.54%（P<0.05）；观察组腰痛减轻时间和肉眼血尿消失时间均短于对照组（P<0.01）；ESWL治疗后7，14 d，观察组SOD水平显著高于对照组（P<0.01），MDA水平低于对照组（P<0.01）；观察组NAG，β2-MG和CysC水平均低于同期对照组（P<0.01）。结论：护肾通淋汤用于肾结石ESWL术后患者，能缩短病程，提高临床疗效，减少并发症，并能抗氧化，减轻肾实质损伤，促进ESWL术后患者的康复。

Abstract

Objective: To observe the protective effect of Hushen Tonglin decoction on kidney injury and its effects on levels of superoxide dismutase in blood serum (SOD) and malonaldehyde (MDA) in patients with kidney calculi after extracorporeal shock-wave lithotripsy (ESWL). Method: One hundred and twenty-eight patients with kidney calculi were randomly divided into control group (63 cases) and observation group (65 cases). Patients of both groups received ESWL treatment

and symptomatic treatment such as anti-infection was given after surgery. Patients in control group received Paishi capsules for 14 days

20 g/time

3 times/day. Patients in observation group took Hushen Tonglin decoction for 14 days

1 dose/day. Time of lumbago relief and disappearance time of gross hematuria were recorded. At the 1th

7th and 14th day after operation

the removed calculi were detected by B-ultrasound. At the 12th hour

7th and 14th day after operation

levels of SOD

MDA

β2-microglobulin (β2-MG)

urinary N-acetyl-β-glucosaminidase (NAG) and cysteine protease inhibitors (CysC) were detected. Result: The effective rate was 93.85%in observation group

higher than 82.54%in control group (P<0.05). The time of lumbago relief and disappearance time of gross hematuria in observation group were shorter than those in control group (P<0.01). At the 7th and 14th day after operation

level of SOD in observation group was higher than that in control group (P<0.01)

and the levels of MDA

NAG

β2-MG and CysC were lower than those in control group (P<0.01). Conclusion: Hushen Tonglin decoction can shorten the disease course

improve clinical efficacy

relieve complications with antioxidant effects

reduce renal parenchyma injury and promote the recovery of patients after ESWL in patients with kidney calculi.

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