Objective: To systematically review the efficacy and safety of Reduning injection for treating hand-foot-mouth disease (HFMD). Method: The Cochrane system evaluation method was used to retrieve such databases as the Cochrane Library

CBM

CNKI and Wanfang Data to collect the randomized controlled trials of Reduning injection in treating HFMD. The meta-analysis was performed using RevMan 5.2 software. Result: The 17 RCTs on Reduning versus Ribavirin involving 2 412 cases

as well as 7 RCTs on Reduning combined with Ribavirin involving 891 cases were included. The results of the Meta-analysis showed that the total treatment efficiency of Reduning group was better than that of Ribavirin[OR=4.71

95%CI (3.46

6.42)

P<0.000 01]

with a shorter fever clearance time[WMD=-1.20

95%CI (-1.44

-0.95)

P<0.000 01]

skin rash regression time[WMD=-1.51

95%CI (-1.95

-1.07)

P<0.000 01]

oral herpes or ulcer regression time[WMD=-1.36

95%CI (-1.76

-0.97)

P<0.000 01]and hospitalization time[WMD=-2.81

95%CI (-3.79

-1.82)

P<0.000 01]

and significant differences. Compared to the Ribavirin group

the group of Reduning combined with Ribavirin was superior than the control group in the total treatment efficiency[OR=5.48

95%CI (3.06

9.80)

P<0.000 01]

fever clearance time[WMD=-1.70

95%CI (-2.05

-1.35)

P<0.000 01]

skin rash regression time[WMD=-1.91

95%CI(-2.99

-0.83)

P<0.000 01]

oral herpes or ulcer regression time[WMD=-1.81

95%CI(-2.09

-1.53)

P<0.000 01]and hospitalization time[WMD=-2.32

95%CI (-3.59

-1.05)

P=0.000 3]

with significant differences. The 24 reports showed that the ADR/ADE of Reduning were lighter than that of Ribavirin

with a higher safety. Conclusion: Actual clinical evidence indicated that the efficacy and safety of the administration with Reduning alone and Reduning combined with Ribavirin was better than the administration with Ribavirin alone in the treatment of HFMD. However

because the reliability of systematic review is restricted by low quality of included study

more high-quality

large-scale and multiple-centered randomized controlled trials should be carried out for further verifying the conclusion.