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纸质出版日期:2016
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吕娜, 赵昱玮, 汲立伟, 等. 黄藤的研究进展[J]. 中国实验方剂学杂志, 2016,22(19):199-202.
LYU Na, ZHAO Yu-wei, JI Li-wei, et al. Review of Fibraurea Recisa[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(19): 199-202.
吕娜, 赵昱玮, 汲立伟, 等. 黄藤的研究进展[J]. 中国实验方剂学杂志, 2016,22(19):199-202. DOI: 10.13422/j.cnki.syfjx.2016190199.
LYU Na, ZHAO Yu-wei, JI Li-wei, et al. Review of Fibraurea Recisa[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(19): 199-202. DOI: 10.13422/j.cnki.syfjx.2016190199.
黄藤是我国的传统中药,其有效成分黄藤素具有疗效显著、副作用低的特征,药用植物黄藤具有越来越广的应用价值。本文通过对国内外相关文献进行整理与分析,综述了黄藤的化学成分和药理作用的最新研究进展,为深入研究黄藤素的化学成分和药理作用提供参考信息。目前的研究表明,黄藤主要含有生物碱、内酯,还含有少量的萜类、醛类、挥发油等化学成分,其中主要的生物碱有黄藤素(盐酸巴马汀)、药根碱,内酯类成分主要以黄藤内酯为主。药理活性研究表明,黄藤的提取物和其所含的化学成分具有抗炎、抑菌、抗病毒、增强免疫力、提高记忆等药理作用,并且关于药理活性的研究主要集中在黄藤素,被当代医学称为是“植物抗生素”。随着国内外对黄藤素的新作用靶点、新疗效的发现,未来黄藤素的国际市场需求很大。但是对于黄藤素的抗炎、抑菌的作用机制尚缺乏相应的深入研究,而且关于黄藤的化学成分研究也有待进一步深入,这也限制了黄藤资源综合的开发利用。本文对黄藤的化学成分和药理活性进行系统的综述,这将为黄藤的深入研究提供参考,也有利于充分开发利用天然药物资源,拓宽黄藤在开发植物药方面新的发展前景,也为黄藤安全、有效的应用于临床提供科学的依据。
Traditional Chinese medicine Fibraureae Caulis boasts efficient ingredients
with low side effects and increasingly wide application value. Based on the analysis of relevant literatures at home and abroad
this article reviewed the study progress of the chemical composition and pharmacological effect of Fibraureae Caulis
and provided the reference for relevant in-depth studies. According to this study
Fibraureae Caulis contained a variety of alkaloids and lactones
as well as a few chemical constituents
such as terpenes
aldehydes
and essential oils. Among them
the main alkaloids were palmatine and jatrorrhizine
and lactones mainly included fibralactone. On the basis of the study on the pharmacological activity
Fibraureae Caulis' extracts and their chemical constituents showed various pharmacological effects
including anti-inflammation
anti-bacteria
anti-virusand improving immunity and memory. And palmatine was the research emphasis
and called ‘plant antibiotics’ by modern medicine. Along with the domestic and foreign discovery of new action targets and new efficacies
palmatine will have great demands in the international market. However
there is still a lack of in-depth study on palmatine's anti-inflammatory and anti-bacterial effects
and the chemical composition also requries further studies. This paper systematically reviewed the chemical constituents and pharmacological activities of Fibraureae Caulis
which will provide the reference for further studies on Fibraureae Caulis
facilitate sufficient development and utilization of natural medicine resources
broaden the new development prospect in the respect of botanical drug
and provide scientific basis in safe and efficient clinical application.
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