运用AHP结合熵权法优化疏风定喘颗粒炙麻黄组的醇沉工艺

李锐华; 孙增涛; 王永香; 刘恩顺; 杨晶; 陆兆光; 李英; 丁岗

doi:10.13422/j.cnki.syfjx.2016200001

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运用AHP结合熵权法优化疏风定喘颗粒炙麻黄组的醇沉工艺

药剂与炮制 | 更新时间：2024-01-04

- 运用AHP结合熵权法优化疏风定喘颗粒炙麻黄组的醇沉工艺
- Optimization of Ethanol Precipitation Process of Zhimahuang Group in Shufeng Dingchuan Granules by Analytic Hierarchy Process and Entropy Method
- 中国实验方剂学杂志 2016年22卷第20期页码：1-5
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家“重大新药创制”科技重大专项（2015ZX09101043-003）
- DOI：10.13422/j.cnki.syfjx.2016200001
  中图分类号： R283.6
- 纸质出版日期：2016
- 稿件说明：
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李锐华, 孙增涛, 王永香, 等. 运用AHP结合熵权法优化疏风定喘颗粒炙麻黄组的醇沉工艺[J]. 中国实验方剂学杂志, 2016,22(20):1-5.

LI Rui-hua, SUN Zeng-tao, WANG Yong-xiang, et al. Optimization of Ethanol Precipitation Process of Zhimahuang Group in Shufeng Dingchuan Granules by Analytic Hierarchy Process and Entropy Method[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(20): 1-5.
李锐华, 孙增涛, 王永香, 等. 运用AHP结合熵权法优化疏风定喘颗粒炙麻黄组的醇沉工艺[J]. 中国实验方剂学杂志, 2016,22(20):1-5. DOI： 10.13422/j.cnki.syfjx.2016200001.

LI Rui-hua, SUN Zeng-tao, WANG Yong-xiang, et al. Optimization of Ethanol Precipitation Process of Zhimahuang Group in Shufeng Dingchuan Granules by Analytic Hierarchy Process and Entropy Method[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(20): 1-5. DOI： 10.13422/j.cnki.syfjx.2016200001.

摘要

目的：运用层次分析法（AHP）结合信息熵权法对多评价指标进行综合评分，优化疏风定喘颗粒炙麻黄组的醇沉工艺，为该药物的制剂工艺研究提供参考。方法：以盐酸麻黄碱、盐酸伪麻黄碱、苦杏仁苷和含固量转移率为综合考察指标，选取醇沉后乙醇体积分数、浓缩液相对密度、静置温度为影响因素进行响应面试验设计，采用AHP结合熵权法确定各指标的权重，实现醇沉工艺的优化。结果：最佳醇沉工艺为醇沉后乙醇体积分数75%，浓缩液相对密度1.10 g·mL-1（25℃），静置温度25℃；在此条件下，盐酸麻黄碱、盐酸伪麻黄碱、苦杏仁苷和含固量转移率依次分别为95.31%，94.91%，96.02%，50.29%。结论：AHP结合信息熵权法的综合评分既能反映中药的君臣佐使，又能体现客观试验数据，适用于疏风定喘颗粒的醇沉工艺优化。

Abstract

Objective: To optimize ethanol precipitation process of Zhimahuang group in Shufeng Dingchuan granules by analytic hierarchy process (AHP) and information entropy method. Method: With the transfer rates of ephedrine hydrochloride

pseudoephedrine hydrochloride

amygdalin and solid-containing content as comprehensive evaluation index

AHP combined with entropy method was applied to determine the weight of each index

response surface test was used to optimize ethanol precipitation process with the concentration of ethanol after ethanol precipitation process

relative density of concentrated solution and temperature of ethanol precipitation process as factors. Result: Optimum ethanol precipitation process was as follows:the concentration of ethanol after ethanol precipitation process of 75%

relative density of concentrated solution of 1.10 g·mL-1 (25℃)

temperature of ethanol precipitation process at 25℃.Under these conditions

transfer rates of ephedrine hydrochloride

pseudoephedrine hydrochloride

amygdalin and solid-containing content were 95.31%

94.91%

96.02%and 50.29%. Conclusion: Comprehensive evaluation of AHP and entropy method can reflect the importance of different traditional Chinese medicine and the objective test data.It is suitable for optimizing ethanol precipitation process of Zhimahuang group in Shufeng Dingchuan granules.

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