Objective: To investigate the effect of alcohol precipitation and compatibility on inhibition of water extract of Artemisia selengensis leaves for Candida albicans. Method: Inhibition of water extract after alcohol precipitation with different concentration for C.albicans was determined by broth microdilution assay

including the inhibition of biomass growth

biofilm formation and germ tube formation.And the effect of compatibility between water extract and other herbs on activity of C.albicans was investigated. Result: Alcohol precipitation significantly reduced the minimum inhibitory concentration (MIC) of water extract to C. albicans

alcohol precipitation with 90%can let MIC80 (down 80%of drug concentration) down from 200 g·L-1 to 8 g·L-1.Besides

the inhibition of biofilm formation and germ tube formation of C. albicans were improved.Among these selected 18 kinds of herbs

Lavandula angustifolia

Scutellaria baicalensis and Curcuma phaeocaulis showed significant synergistic effect for inhibition of C. albicans(factional inhibitory concentration index was less than 0.5).MIC80 of water extract was reduced to 0.60 g·L-1 when combined with S. baicalensis. Conclusion: Alcohol precipitation and compatibility of water extract of A. selengensis leaves can improve its inhibitory activity for C. albicans.