Objective: To predict the ecologically adaptable area of Scutellariae Radix in China

and study the effects of twenty environmental variables on the five main chemical components

in order to provide reference to introduction and cultivation of Scutellariae Radix. Method: Maxent model was used to study the ecological adaptability of Scutellariae Radix. The ultra-high performance liquid chromatography was used to determine the five main chemical components

namely including baicalin

wogonoside

baicalein

wogonin and oroxylin

and multiple linear regressions were adopted to study the effects of environmental variables on the chemical components. Result: The most adaptable area for Scutellariae Radix is located in the southern ridges of Greater Hinggan Mountains and Yanshan Mountain

with the adaptability declining towards both edges of the ridges. And the chemical components in the herbs were closely correlated with the environmental variables

especially the variation of temperature and precipitation. Conclusion: This study determines the ecologically adaptable area of Scutellariae Radix in China

and explores the effect of environmental variables on the chemical components in Scutellariae Radix.