Objective: To observe the effects of Qinling liquid on renal function and pathological changes of renal tissue in rats with uric acid nephropathy

and to discuss its protection mechanism for renal injury. Method: The rat model was induced by gavaging adenine and feeding yeast.Model rats were randomly divided into the normal group

the model group

the positive group (23.33 mg·kg-1·d-1 of allopurinol) and high-dose

medium-dose

low-dose groups of Qinling liquid (36.4

18.2

9.1 g·kg-1·d-1)

the normal group and the model group were daily gavaged with distilled water.At the timepoint of 0

2

4

6

8 weeks

the levels of serum uric acid (sUA)

serum creatinine (sCR)

blood urea nitrogen (BUN) and 24 h urine protein (uPRO/24 h) were detected.At the end of 6th and 8th week

half of rats in each group were sacrificed and the kidney was harvested for hematoxylin-eosin and periodic acid-schiff staining. Result: Compared with the normal group

the levels of uPRO/24 h

sUA

sCR and BUN in the model group were dramatically inceased

pathological changes of renal tissue were serious.Compared with the model group

the levels of uPRO/24 h

sUA

sCR and BUN in each group of Qinling liquid were deceased at different degrees

and the pathological changes of renal tissue were alleviated. Conclusion: In model rats of uric acid nephropathy

Qinling liquid can significantly improve renal function and relieve renal pathological damage for kidney protection.