麻杏调肺汤通过抑制炎症反应治疗慢性阻塞性肺病的探讨

姬洁莹; 郭阿霞; 张玮玮

doi:10.13422/j.cnki.syfjx.2016200127

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麻杏调肺汤通过抑制炎症反应治疗慢性阻塞性肺病的探讨

药理 | 更新时间：2024-01-04

- 麻杏调肺汤通过抑制炎症反应治疗慢性阻塞性肺病的探讨
- Study of Maxing Tiaofei Tang in Reatment of Chronic Obstructive Pulmonary Disease by Inhibiting Inflammatory Reactions
- 中国实验方剂学杂志 2016年22卷第20期页码：127-131
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- DOI：10.13422/j.cnki.syfjx.2016200127
  中图分类号： R259
- 纸质出版日期：2016
- 稿件说明：
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姬洁莹, 郭阿霞, 张玮玮. 麻杏调肺汤通过抑制炎症反应治疗慢性阻塞性肺病的探讨[J]. 中国实验方剂学杂志, 2016,22(20):127-131.

JI Jie-ying, GUO A-xia, ZHANG Wei-wei. Study of Maxing Tiaofei Tang in Reatment of Chronic Obstructive Pulmonary Disease by Inhibiting Inflammatory Reactions[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(20): 127-131.
姬洁莹, 郭阿霞, 张玮玮. 麻杏调肺汤通过抑制炎症反应治疗慢性阻塞性肺病的探讨[J]. 中国实验方剂学杂志, 2016,22(20):127-131. DOI： 10.13422/j.cnki.syfjx.2016200127.

JI Jie-ying, GUO A-xia, ZHANG Wei-wei. Study of Maxing Tiaofei Tang in Reatment of Chronic Obstructive Pulmonary Disease by Inhibiting Inflammatory Reactions[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(20): 127-131. DOI： 10.13422/j.cnki.syfjx.2016200127.

摘要

目的：探讨麻杏调肺汤对慢性阻塞性肺病（COPD）的治疗效果，为后期的研究提供实验依据。方法：SD大鼠采用香烟烟雾暴露联合气管注射脂多糖（0.1 mL）法制造COPD大鼠模型，随机分为5组，分别为模型组，醋酸泼尼松组（3.3 mg·kg-1·d-1），麻杏调肺汤低、中、高剂量组（1.7，3.4，6.8 g·kg-1·d-1），另设正常组，每组10只。待伤口愈合7 d后开始给药，连续5周；采用酶联免疫吸附测定（ELISA）法检测血清中肿瘤坏死因子-α（TNF-α），核转录因子-κB（NF-κB），白细胞介素-1β（IL-1β），IL-8，IL-10；观察肺功能情况及肺病理组织学变化。结果：与正常组比较，模型组大鼠细胞因子TNF-α，NF-κB，IL-1β，IL-8含量明显升高，IL-10含量明显降低（P<0.01），肺部组织的病变明显，肺功能明显降低；与模型组比较，麻杏调肺汤高剂量组能明显降低大鼠细胞因子TNF-α，NF-κB，IL-1β，IL-8，升高IL-10含量（P<0.05，P<0.01）；减轻肺部组织的病变程度，改善肺功能。结论：麻杏调肺汤通过调节炎症反应中相关细胞因子TNF-α，NF-κB，IL-1β，IL-8，IL-10治疗COPD模型大鼠，并对肺脏具有的保护作用。

Abstract

Objective: To discuss the therapeutic effect of Maxing Tiaofei Tang for chronic obstructive pulmonary disease(COPD) and explore its action mechanism. Method: The models of COPD rats were established by smoking exposure combined with intratracheal injection of lipopolysaccharide(0.1 mL). These SD rats were randomly divided into normal group

model group

prednisone acetate group(3.3 mg·kg-1·d-1)

Maxing Tiaofei Tang low-dose group(1.7 g·kg-1·d-1)

mid-dose group(3.4 g·kg-1·d-1)

and high-dose group(6.8 g·kg-1·d-1)

n=10 in each group. The drugs were administered 7 days after wound healing for 5 weeks. The levels of tumor necrosis factor-α(TNF-α)

nuclear factor-κB(NF-κB)

interleukin-1β(IL-1β)

IL-8 and IL-10 in serum were detected by ELISA; pulmonary functions and pathological changes were observed. Result: As compared with the normal group

the levels of TNF-α

NF-κB

IL-1β and IL-8 were significantly increased in model group; the level of IL-10 was significantly decreased(P<0.01); the lesions in pulmonary tissues were obvious; pulmonary functions were significantly decreased. As compared with the model group

Maxing Tiaofei Tang high-dose group could reduce the levels of TNF-α

NF-κB

IL-1β and IL-8

and increase the level of IL-10 in serum of the COPD rats(P<0.05

P<0.01); reduce the degree of pathological changes in lung tissues and improve the pulmonary functions. Conclusion: The mechanism of Maxing Tiaofei Tang for the COPD rats may be associated with regulating the levels in TNF-α

NF-κB

IL-1β

IL-8 and IL-10 in inflammatory reaction

and it has a protective effect for lungs.

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