Objective: To observe the effect of Yiqi Huayu Jiedu decoction combined with endoscopic microcosmic syndrome differentiation in treating chronic atrophic gastritis

and discuss its action mechanism. Method: Totally 120 cases of chronic atrophic gastritis patients were randomly divided into two groups

with 60 in each group. The control group was orally given Weifuchun table (4 pills/time

tid)

Treatment group was orally given Yiqi Huayu Jiedu decoction and other traditional Chinese medicines(TCM) on the basis of endoscopic microcosmic syndrome differentiation. The treatment of both groups lasted for 16 weeks to observe clinical symptoms

score of symptoms

mucosal lesions and microscopic signs of both groups under gastroscope before and after treatment. Result: At the end of the treatment

the total effective rates of treatment group and control group were 83.3%and 70%

respectively

their total effective rates of gastric mucosa were 73.3%and 60%

respectively. Treatment group was better than control group in the total score of symptoms and the TCM syndrome score (P<0.05). Treatment group can significantly improve gastric mucosal histopathology and microscopic signs under gastroscope

with a better effect in resisting helicobacter pylori (P<0.05). Conclusion: Yiqi Huayu Jiedu decoction combined with endoscopic microcosmic syndrome differentiation has a definite efficacy in treating chronic atrophic gastritis

and so is worth promoting in clinic.