Objective: To compare quality control indexes and chemical compositions of crude Psoraleae Fructus and its three processed products. Method: Impurity

water content

total ash and acid insoluble ash of different processed products were performed in accordance with standards in the 2015 edition of Chinese Pharmacopoeia.HPLC was established to compare contents of major ingredients in crude Psoraleae Fructus and its different processed products. Result: The impurity

water content

total ash and acid insoluble ash of crude Psoraleae Fructus and its three processed products met requirements of the 2015 edition of Chinese Pharmacopoeia.Twelve major constituents were identified. Conclusion: Bakuchiol has renal toxicity and liver toxicity.After processing

the content of bakuchiol decreases

indicating that wine and salt processed products can attenuate toxicity of crude products;psoralen and isopsoralen significantly increase

these two components can promote growth of osteoblasts

which was in consistent with theory that salt processing can enhance kidney-Yang effect.The content of 4'-O-methylbroussochalcone B significantly increases in processed products

whereas bavachinin A significantly reduces

which may be due to that bavachinin A degrades and turns into 4'-O-methylbroussochalcone B at high temperatures.Variations in contents of these constituents in Psoraleae Fructus may contribute to different clinical efficacy of its processed products.