Objective: To investigate the correlation between sulfur dioxide residue and the content of sulfur-containing derivatives in Angelica Sinensis Radix after sulfur-fumigation. Method: The method in Chinese Pharmacopoeia (2010 version

the first supplement) was used to determine the dynamic change of sulfur dioxide residue; UPLC-QTOF-MS/MS method was used to quantify the sulfur-containing derivatives at different sulfur-fumigation time points. The determination results of sulfur dioxide residue and sulfur-containing derivatives were statistically analyzed. Result: With the increase of sulfur-fumigation duration

sulfur dioxide residue first increased

then reduced and became flat within 480 min. The content of sulfur-containing derivatives in decoction was obviously higher than that in methanol extract

and first increased and then slowly reduced with the increase of sulfur-fumigation duration. Conclusion: There is no clear correlation between sulfur dioxide residue and sulfur-containing derivatives in sulfur-fumigated Angelica Sinensis Radix. Therefore

sulfur dioxide residue alone might be inadequate to comprehensively evaluate the quality control of sulfur-fumigated Angelica Sinensis Radixs.