Objective: To observe the clinical efficacy of Qingre Lishi Zhuyu decoction in treating gouty arthritis

and investigate its action mechanism. Method: The 210 patients with gouty arthritis admitted to Orthopedic Department of Heibei Hospital of Traditional Chinese Medicine from September

2014 to September

2015 were divided into treatment group and control group according to the digital random table method

with 105 cases in each group. Patients in control group received western medicines colchicine

dextral ketone ibuprofen tromethamine tablets

while patients in treatment group were treated with Qingre Lishi Zhuyu decoction. The improvement in scores of main symptoms and signs

erythrocyte sedimentation rate (ESR)

uric acid (UA)

C-reactive protein (CRP)

and interleukin 1β (IL-1β) after treatment were compared between two groups

the relief time for main symptoms and signs

as well as the total effective rate were compared between two groups. Patients of two groups were followed up for 3 months

and the recurrence rate within three months were compared between two groups. Result: The total effective rate of treatment group was higher than that of control group after treatment (P<0.05)

scores of main symptoms and signs

ESR

UA

CRP

IL-1β improvement in treatment group were better than those of control group (P<0.01)

alleviate time of joint pain and swelling in treatment group was less than that of control group (P<0.05)

the incidence of adverse reactions and the recurrence rate within 3 months were lower than those of control group (P<0.05). Conclusion: Qingre Lishi Zhuyu decoction can effectively alleviate inflammation

improve clinical symptoms

and reduce the recurrence rate in treating gouty arthritis

with significant clinical efficacy and good safety.