Objective: To discuss the curative effect and mechanism of action of modified Lianggesan combined with western therapy in treating erosive oral lichen planus (EOLP) with syndrome of accumulated heat in heart and spleen for adolescent patients. Method: Eighty patients were divided into western medicine group (40 cases) and observation group (40 cases) by random number table

with 20 cases for healthy control group. Patients in western medicine group were injected with triamcinolone acetonide acetate injection and lidocaine hydrochloride injection mixed suspension

1 time/week

for consecutively 4 weeks

and vitamin A and C tablets for consecutively 12 weeks. In addition to the therapy of western medicine group

patients in observation group took modified Lianggesan for consecutively 12 weeks

1 dose/day. Before and after the treatment

scores of symptoms and signs were recorded. Levels of nuclear factor-κB (NF-κB)

total antioxidant capacity (TAC)

malondialdehyde (MDA)

nitric oxide (NO) in serum and saliva and levels of thrombomodulin (TM)

C-reactive protein (CRP) and endothelin-1 (ET-1) were detected. And adverse reactions were recorded. Result: Sores of symptoms and signs in observation group were lower than those in western medicine group (P<0.01). The total clinical effect rate in observation group was 95%

which was higher than 77.5% in western medicine group (P<0.05). Compared with the healthy group

before the treatment

the two groups showed significantly increases in levels of NF-κB

NO and MDA

but with remarkable decrease in TAC (P<0.01). After the treatment

observation group showed lower NF-κB

NO and MDA but higher TAC in serum and saliva than western medicine group (P<0.01)

and higher NF-κB

NO and MDA but lower TAC in serum and saliva than healthy group (P<0.01). Compared with the healthy group

Before the treatment

the two groups showed significantly increases in levels of TM

CRP and ET-1 (P<0.01). After the treatment

observation group showed significantly lower levels of TM

CRP and ET-1 than western medicine group

but still higher than healthy group (P<0.01). And there was no adverse reaction in the two groups. Conclusion: Modified Lianggesan combined with western therapy shows a significant effect in treating erosive oral lichen planus (EOLP) with syndrome of accumulated heat in heart and spleen of adolescent patients. Its mechanism of action may be correlated with relieving inflammatory response

resisting oxidative stress and protecting vascular endothelial cell.