补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价

魏晓晨; 王慧; 朱立勤; 王春革; 邓琦; 李新

doi:10.13422/j.cnki.syfjx.2016220186

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补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价

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- 补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价
- Systematic Evaluation of Efficacy and Safety of Buyang Huanwu Tang in Preventing Oxaliplatin-induced Peripheral Neurotoxicity in Cancer Patients
- 中国实验方剂学杂志 2016年22卷第22期页码：186-190
- 作者机构：
- 作者简介：
- 基金信息：
  
  天津市卫生局科技项目（2014KY09）
- DOI：10.13422/j.cnki.syfjx.2016220186
  中图分类号： R730.5
- 纸质出版日期：2016
- 稿件说明：
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魏晓晨, 王慧, 朱立勤, 等. 补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价[J]. 中国实验方剂学杂志, 2016,22(22):186-190.

WEI Xiao-chen, WANG Hui, ZHU Li-qin, et al. Systematic Evaluation of Efficacy and Safety of Buyang Huanwu Tang in Preventing Oxaliplatin-induced Peripheral Neurotoxicity in Cancer Patients[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(22): 186-190.
魏晓晨, 王慧, 朱立勤, 等. 补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价[J]. 中国实验方剂学杂志, 2016,22(22):186-190. DOI： 10.13422/j.cnki.syfjx.2016220186.

WEI Xiao-chen, WANG Hui, ZHU Li-qin, et al. Systematic Evaluation of Efficacy and Safety of Buyang Huanwu Tang in Preventing Oxaliplatin-induced Peripheral Neurotoxicity in Cancer Patients[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(22): 186-190. DOI： 10.13422/j.cnki.syfjx.2016220186.

摘要

目的：系统评价补阳还五汤（BYHWT）预防奥沙利铂所致周围神经毒性（OIPN）的疗效及安全性。方法：全面检索PubMed，EMbase，Cochrane Libraries，CNKI，维普和万方数据库中收录的BYHWT预防OIPN疗效的随机对照试验（RCT），检索时限均从建库至2015年9月。在资料提取和质量评价后，采用RevMan 5.3软件进行Meta分析。结果： ①共纳入8个RCT，包括489例患者。Meta分析显示BYHWT组与对照组在OIPN总发生率、严重OIPN发生率及外周神经传导速度方面具有统计学差异；BYHWT组与甲钴胺组在OIPN总发生率及严重OIPN发生率方面具有统计学差异。②纳入所有研究均未发现与BYHWT相关的不良反应发生。结论： BYHWT能有效预防OIPN的发生，降低OIPN的发生率，且安全性较好，受纳入研究数量和质量所限，上述结论尚需更多大样本、多中心、高质量的随机对照试验来加以验证。

Abstract

Objective: To assess the efficacy and safety of Buyang Huanwu Tang (BYHWT) in preventing oxaliplatin-induced peripheral neurotoxicity (OIPN) in cancer patients. Method: PubMed

EMbase

Cochrane Libraries

CNKI

Wanfang and VIP databases were retrieved from the date of establishment until September 2015.Randomized controlled trials (RCTs) evaluating the efficacy of BYHWT in preventing OIPN in cancer patients were collected. Statistical analysis was performed with RevMan 5.3. Result: ① Eight RCTs involving 489 patients were included. The results of Meta-analyses showed statistically significant differences in total incidence of OIPN

incidence of severe OIPN and peripheral nerve conduction velocity between BYHWT group and control group; ② All of the studies included showed no adverse reaction induced by BYHWT. Conclusion: BYHWT is safe and effective in preventing OIPN and reducing the incidence of OIPN. However

due to the restrictions in the quantity and quality of the included studies

more multicenter high-quality RCTs with large sample size are needed to verify the above conclusion.

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