吴茱萸对黄连有效成分在大鼠体内组织分布的影响

梁瑞峰; 张峰; 李更生; 时丽菲

doi:10.13422/j.cnki.syfjx.2016230089

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吴茱萸对黄连有效成分在大鼠体内组织分布的影响

药物代谢 | 更新时间：2024-01-04

- 吴茱萸对黄连有效成分在大鼠体内组织分布的影响
- Effect of Euodiae Fructus on Tissue Distribution of Active Components from Coptidis Rhizoma in Rats
- 中国实验方剂学杂志 2016年22卷第23期页码：89-93
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81403124）
- DOI：10.13422/j.cnki.syfjx.2016230089
  中图分类号： R285.5
- 纸质出版日期：2016
- 稿件说明：
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梁瑞峰, 张峰, 李更生, 等. 吴茱萸对黄连有效成分在大鼠体内组织分布的影响[J]. 中国实验方剂学杂志, 2016,22(23):89-93.

LIANG Rui-feng, ZHANG Feng, LI Geng-sheng, et al. Effect of Euodiae Fructus on Tissue Distribution of Active Components from Coptidis Rhizoma in Rats[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 89-93.
梁瑞峰, 张峰, 李更生, 等. 吴茱萸对黄连有效成分在大鼠体内组织分布的影响[J]. 中国实验方剂学杂志, 2016,22(23):89-93. DOI： 10.13422/j.cnki.syfjx.2016230089.

LIANG Rui-feng, ZHANG Feng, LI Geng-sheng, et al. Effect of Euodiae Fructus on Tissue Distribution of Active Components from Coptidis Rhizoma in Rats[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 89-93. DOI： 10.13422/j.cnki.syfjx.2016230089.

摘要

目的：考察吴茱萸对左金丸中盐酸小檗碱、盐酸巴马汀和盐酸药根碱在大鼠组织中分布动力学的影响，探讨吴茱萸的引经作用机制。方法：大鼠分别灌胃给予黄连、黄连吴茱萸合煎液，于给药后不同时间点采集组织样本，利用UPLC-MS/MS测定组织中3种黄连生物碱类成分的经时变化，采用DAS 2.0软件计算组织分布动力学参数、相对摄取率（Re）和峰浓度比（Ce）。结果：左金丸组大鼠肝组织中盐酸小檗碱和盐酸巴马汀的药-时曲线下面积分别为（7 051.268±518.354），（2 179.139±195.617）ng·g-1·h，药峰浓度分别为（1 645.961±129.862），（383.889±19.526）ng·g-1，与黄连组比较显著增加。3种生物碱类成分的在肝中Re分别为1.338，1.475和1.065，Ce分别为1.548，1.751和1.369；肺中Re分别为0.985，0.780和0.930，Ce分别为0.834，1.051和0.905。结论：吴茱萸可能是通过增加黄连生物碱类成分在大鼠肝中分布和减少其在肺中分布来发挥引经作用。

Abstract

Objective: To observe the effect of Euodiae Fructus on tissue distribution kinetics of berberine hydrochloride

palmatine hydrochloride and jatrorrhizine hydrochloride from Coptidis Rhizoma in rats. Method: Rats were administered respectively by Coptidis Rhizoma and codecoction of Coptidis Rhizoma and Euodiae Fructus.Tissue samples were collected at diferent time after administration.The variation of berberine hydrochloride

palmatine hydrochloride and jatrorrhizine hydrochloride with time was determined by UPLC-MS/MS.The kinetic parameters

relative uptake rate (Re) and peak concentration ratio (Ce) were calculated by DAS 2.0 software. Result: In group of codecoction of Coptidis Rhizoma and Euodiae Fructus

AUC0-∞ of berberine hydrochloride and palmatine hydrochloride distributed in the liver tissues were (7 051.268±518.354)

(2 179.139±195.617) ng·g-1·h

Cmax were (1 645.961±129.862)

(383.889±19.526) ng·g-1;compared with the Coptidis Rhizoma group

they were increased significantly.Re of these three alkaloids in liver were 1.338

1.475 and 1.065

Ce of them in liver were 1.548

1.751 and 1.369

Re of them in lung were 0.985

0.780 and 0.930

Ce of them in lung were 0.834

1.051 and 0.905. Conclusion: Euodiae Fructus has properties of reducing the distribution of alkaloids from Coptidis Rhizoma in the lung and increasing their distribution in the liver.

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