Objective: To observe the effects of Xiangsha Zhizhu granules on the clinical symptoms of gastrointestinal hormones

gastric emptying time

and symptom scores of patients with spleen and stomach deficiency type functional dyspepsia (FD)

and explore its therapeutic effect. Method: The 120 FD patients with spleen and stomach deficiency were randomly divided into two groups:treatment group (60 cases) and control group (60 cases). Patients in treatment group received Xiangsha Zhizhu granules treatment

and patients in control group received domperidone treatment

with a treatment course of 2 weeks for both groups. The indicators of gastrointestinal hormone (acetylcholinesterase and motilin) and symptom scores were evaluated to observe the therapeutic effect of two groups and compare the difference between two groups. Result: The levels of acetylcholinesterase and motilin were significantly improved in two groups of FD patients after treatment (P<0.05)

and the levels in treatment group was significantly higher than those in control group (P<0.05)

the gastric emptying time was significantly shortened in both groups after treatment (P<0.05)

the symptom index scores were decreased in both groups after treatment (P<0.05)

and some indexes in treatment group achieved better effect than those in control group (P<0.05)

the overall efficacy was obvious in both groups

and the efficacy of the treatment group was significantly better than that of control group (P<0.05). Conclusion: Xiangsha Zhizhu granules have obvious effect on the clinical symptoms of patients with spleen and stomach deficiency type FD

and the mechanism may be associated with promoting stomach power of FD patients by regulating gastrointestinal hormone

so it can be used widely in clinical treatment.