养阴降压胶囊联合降浊祛瘀颗粒治疗高血压合并代谢综合征的临床分析

张国荣; 易小红; 尹礼烘; 周裔忠; 聂薇

doi:10.13422/j.cnki.syfjx.2016230171

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养阴降压胶囊联合降浊祛瘀颗粒治疗高血压合并代谢综合征的临床分析

临床 | 更新时间：2024-01-04

- 养阴降压胶囊联合降浊祛瘀颗粒治疗高血压合并代谢综合征的临床分析
- Clinical Effect of Yangyin Jiangya Capsule Combined with Jiangzhuo Quyu Granule in Treatment of Hypertension with Metabolic Syndrome
- 中国实验方剂学杂志 2016年22卷第23期页码：171-175
- 作者机构：
- 作者简介：
- 基金信息：
  
  南昌市科技局医学基金项目（20161003）
- DOI：10.13422/j.cnki.syfjx.2016230171
  中图分类号： R589;R544.1
- 纸质出版日期：2016
- 稿件说明：
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张国荣, 易小红, 尹礼烘, 等. 养阴降压胶囊联合降浊祛瘀颗粒治疗高血压合并代谢综合征的临床分析[J]. 中国实验方剂学杂志, 2016,22(23):171-175.

ZHANG Guo-rong, YI Xiao-hong, YIN Li-hong, et al. Clinical Effect of Yangyin Jiangya Capsule Combined with Jiangzhuo Quyu Granule in Treatment of Hypertension with Metabolic Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 171-175.
张国荣, 易小红, 尹礼烘, 等. 养阴降压胶囊联合降浊祛瘀颗粒治疗高血压合并代谢综合征的临床分析[J]. 中国实验方剂学杂志, 2016,22(23):171-175. DOI： 10.13422/j.cnki.syfjx.2016230171.

ZHANG Guo-rong, YI Xiao-hong, YIN Li-hong, et al. Clinical Effect of Yangyin Jiangya Capsule Combined with Jiangzhuo Quyu Granule in Treatment of Hypertension with Metabolic Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(23): 171-175. DOI： 10.13422/j.cnki.syfjx.2016230171.

摘要

目的：探讨养阴降压胶囊联合降浊祛瘀颗粒治疗高血压（EH）合并代谢综合征（MS）的临床疗效及对炎症因子和血管内皮功能的影响。方法：将169例患者随机按数字表法分为对照组84例和观察组85例。对照组采用替米沙坦片，口服，80 mg/次，1次/d；血压不能控制者加服硝苯地平缓释片，0.1~0.2 g/次，1次/d；血脂异常者，口服阿托伐他汀钙片，10 mg/次，1次/d；采用口服降糖药物或胰岛素控制血糖。观察组在对照组治疗的基础上加用养阴降压胶囊，口服，4粒/次，3次/d；和降浊祛瘀颗粒，6 g/次，2次/d，温开水冲服。两组疗程均为12周。测量治疗前后血压水平；测量体重（Wt），腰围（WC）和臀围，计算腰臀比（WHR）和体质指数（BMI）；检测治疗前后甘油三酯（TG），高密度脂蛋白胆固醇（HLD），总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C），空腹血糖（FBG），餐后2 h血糖（2 h PG），糖化血红蛋白（HbA1c），空腹胰岛素（FINS）水平，并计算胰岛素敏感指数（ISI）和胰岛素抵抗指数（HOMA-IR）；进行治疗前后中医证候评分；检测治疗前后白细胞介素-6（IL-6），超敏C反应蛋白（hs-CRP），假性血友病因子（vWF），脂联素（APN）和瘦素（LP）水平。结果：观察组治疗后血压疗效总有效率为95.29%，对照组为84.52%，观察组高于对照组（P<0.05）；治疗后观察组SBP，DBP，WC，WHR水平均低于对照组（P<0.05）；观察组FBG，2 h PG，HbA1c，HOMA-IR水平均低于对照组，ISI高于对照组（P<0.01）；观察组TG和LDL-C水平均低于对照组，HDL-C水平高于对照组（P<0.01）；观察组APN高于对照组，LP，hs-CRP，IL-6和vWF水平均低于对照组（P<0.01）。结论：在西医常规治疗的基础上，加用养阴降压胶囊和降浊祛瘀颗粒内服治疗EH合并MS患者，能进一步的控制血压，改善症状，调节糖、脂代谢，改善胰岛素抵抗，能减轻炎症反应，调节血管内皮功能，降低心血管疾病（CVD）的危险因素。

Abstract

Objective: To discuss the clinical efficacy of Yangyin Jiangya capsule combined with Jiangzhuo Quyu granule in treating hypertension (EH) with metabolic syndrome (MS)

and its effect on inflammatory response and vascular endothelial function. Method: One hundred and sixteen-nigh patients were divided into control group (84 cases) and observation group (85 cases) by random number table. Patients in control group got Telmisartan tablets

80 mg/time

qd. Patients whose blood pressure cannot be controlled were additionally given with nifedipine sustained release tablets

0.1-0.2 g/time

qd. Patients with dyslipidemia were additionally given with atorvastatin calcium tablets

10 mg/time

qd. And their blood glucose was controlled by hypoglycemic agent or insulin. In addition to the therapy of control group

patients in observation group were additionally given with Yangyin Jiangya capsule

4 grains/time

tid Jiangzhuo Quyu granule

6 g/time

bid

the courses of treatment were 12 weeks. Before and after treatment

levels of blood pressure

weight (WT) and waist circumference (WC) were detected

Waist-hip ratio (WHR) and body mass index (BNI) were calculated. And levels of triacylglycerol (TG)

high density lipoprotein cholesterol (HLD)

total cholesterol (TC)

low density lipoprotein (LDL-C)

fasting blood-glucose (FBG)

blood glucose after 2 hours of meal (2 h PG)

glycosylated hemoglobin (HbA1c)

and fasting insulin (FINS) were detected

and insulin sensitivity index (ISI) and insulin resistance index (HOMA-IR) were calculated. And traditional Chinese medicine(TCM) symptoms were scored

and levels of interleukin-6 (IL-6)

rabbit high sensitivity C-reactive protein (hs-CRP)

von Willebrand factor (vWF)

Adiponectin (APN) and Leptin (LP) were detected. Result: The total rate of effect of blood pressure in observation group was 95.29%

which was higher than 84.52% in control group (P<0.05). After treatment

levels of SBP

DBP

WC and WHR in observation group were lower than those in control group (P<0.05). And FBG

2 h PG

HbA1c

HOMA-IR

LDL-C

hs-CRP

IL-6 and vWF were lower than those in control group

and levels of ISI

HDL-C and APN were higher than that in control group (P<0.01). Conclusion: In addition to the therapy of routine western medicine treatment

Yangyin Jiangya capsule combined with Jiangzhuo Quyu granule can further control blood pressure

ameliorate symptoms and insulin resistance

regulate sugar and lipid metabolism and vascular endothelial function

relieve nflammatory response

reduce cardiovascular diseases(CVD) hazards.

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