复方黄柏液促进糖尿病足溃疡愈合及其中AGEs与炎性因子的相关性

郑琪; 李友山; 冀凌云

doi:10.13422/j.cnki.syfjx.2016240167

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复方黄柏液促进糖尿病足溃疡愈合及其中AGEs与炎性因子的相关性

临床 | 更新时间：2024-01-04

- 复方黄柏液促进糖尿病足溃疡愈合及其中AGEs与炎性因子的相关性
- Effect of Compound Cortex Phellodendri Fluid on AGEs and Inflammatory Factors in Promoting Healing Process of Diabetic Foot Ulcer
- 中国实验方剂学杂志 2016年22卷第24期页码：167-171
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81302980）
- DOI：10.13422/j.cnki.syfjx.2016240167
  中图分类号： R259
- 纸质出版日期：2016
- 稿件说明：
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郑琪, 李友山, 冀凌云. 复方黄柏液促进糖尿病足溃疡愈合及其中AGEs与炎性因子的相关性[J]. 中国实验方剂学杂志, 2016,22(24):167-171.

ZHENG Qi, LI You-shan, JI Ling-yun. Effect of Compound Cortex Phellodendri Fluid on AGEs and Inflammatory Factors in Promoting Healing Process of Diabetic Foot Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(24): 167-171.
郑琪, 李友山, 冀凌云. 复方黄柏液促进糖尿病足溃疡愈合及其中AGEs与炎性因子的相关性[J]. 中国实验方剂学杂志, 2016,22(24):167-171. DOI： 10.13422/j.cnki.syfjx.2016240167.

ZHENG Qi, LI You-shan, JI Ling-yun. Effect of Compound Cortex Phellodendri Fluid on AGEs and Inflammatory Factors in Promoting Healing Process of Diabetic Foot Ulcer[J]. Chinese journal of experimental traditional medical formulae, 2016, 22(24): 167-171. DOI： 10.13422/j.cnki.syfjx.2016240167.

摘要

目的：探讨复方黄柏液促进糖尿病足溃疡愈合过程中对炎性因子的影响，观察其促进创面组织愈合的作用。方法：选择2014年5月—2015年6月东直门医院确诊的糖尿病足溃疡湿热毒盛证患者120例，随机分为治疗组和对照组，各60例，治疗组局部外用复方黄柏液，对照组外用康复新液，每日换药1次。于用药前0 d，用药后7，14，21，28 d分别抽取静脉血，动态监测血清中超敏C反应蛋白（high sensitive C reactive protections，hs-CRP），肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α），白细胞介素-6（interleukin-6，IL-6），晚期糖基化终末化产物（advanced glycation end-products，AGEs）动态变化情况，治疗4周后，观察两组临床症状改善情况。结果：在炎症反应的早期，两组患者hs-CRP，TNF-α，IL-6均明显上升（P<0.05），第7，14，21，28天，治疗组和对照组均可明显降低hs-CRP，TNF-α，IL-6水平（P<0.05），其中，治疗组效果优于对照组（P<0.05）；与对照组比较，第7，14，21，28天治疗组和对照组AGEs水平均呈下降趋势，与对照组比较，治疗组AGEs下降明显（P<0.05），动态分析认为AGEs与炎性因子呈显著正相关；患者在主证积分、次证积分方面的改善治疗组均优于对照组（P<0.05），经复方黄柏液治疗的治疗组总有效率83.3%，对照组总有效率71.6%，治疗组总疗效优于对照组（P<0.05）。结论：复方黄柏液对糖尿病足溃疡湿热毒盛证患者治疗有效，值得临床推广。

Abstract

Objective: To discuss the effect of Compound Cortex Phellodendri fluid on inflammatory factors in promoting the healing process of diabetic foot ulcers

and observe its effect in promoting wound tissue healing. Method: Totally 120 patients with diabetic foot ulcers of toxic heat syndrome diagnosed in Dongzhimen Hospital between May 2014 and June 2015 were selected and randomly divided into treatment and control groups (with 60 cases in each group). Treatment group was locally administered with Compound Cortex Phellodendri fluid

while control group was locally administered with Kangfuxin solution

with once dressing change per day. At 0 d before administration and 7

21 and 28 d after administration

venous blood was collected to observe dynamic changes in high sensitive C reactive protections (hs-CRP)

tumor necrosis factor-α(TNF-α)

interleukin-6 (IL-6) and advanced glycation end-products (AGEs). Four weeks after treatment

improved clinical symptoms and dynamic changes in inflammatory factors of AGEs of both groups were analyzed statistically. Result: Treatment group showed the total efficiency of 81.3%

while control group showed the total efficiency of 68.8%

indicating total treatment group was superior to control group. At early stage of inflammatory reaction

both groups showed significant increases in hs-CRP

TNF-α and IL-6 (P<0.05)

at 7

21 and 28 d after administration

treatment group and control group showed significant decreases in hs-CRP

TNF-α and IL-6(P<0.05)

with a better efficacy in treatment group than control group (P<0.05); compared with control group

at 7

21 and 28 d after administration

treatment group and control group showed a declining trend in AGEs

with the lower AGEs in treatment group than control group (P<0.05). According to the dynamic analysis

AGEs were positively related to inflammatory factors

treatment group was superior to control group in principal syndrome integral and secondary syndrome integral (P<0.05). Conclusion: Compound Cortex Phellodendri fluid has a therapeutic effect in treating diabetic foot ulcer with toxic heat syndrome

and is worth clinical promotion.

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