Objective: The calcium element in Qingkailing injection and its crude medicine were analyzed to clarify the calcium content

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differences between ten batches and whether calcium element is the pharmacodynamics material basis in Qingkailing injection. Method: The Qingkailing injection and crude medicine were prepared by microwave resolution method; the calcium element was detected by inductively coupled plasma-mass spectrometry (ICP-MS). Meanwhile the data was analyzed by relevant informatics research. Result: Concha margaritifera and Radix isatis were the major providers of calcium element in Qingkailing injection. The RSD of different batches Qingkailing injection was more than 40%. The concentration of plasma calcium element had no statistically significant differences after rat receiving intravenously Qingkailing injection compared to that of rats of control group. Conclusion: The modern preparing technology of Qingkailing injection lead to the loss of calcium

and the concentration of plasma calcium element was not increased by the calcium element of Qingkailing injection. Therefore

further research would be needed to understand whether the calcium element was the pharmacodynamics material basis of Qingkailing injection.